Literature DB >> 21151743

Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure.

Nir Qvit1, Daria Mochly-Rosen.   

Abstract

Heart failure (HF) in which the blood supply does not match the body's needs, affects 10% of the population over 65 years old. The protein kinase C (PKC) family of kinases has a key role in normal and disease states. Here we discuss the role of PKC in HF and focus on the use of specific PKC regulators to identify the mechanism leading to this Pathology and potential leads for therapeutics.

Entities:  

Year:  2010        PMID： 21151743      PMCID： PMC2998291          DOI： 10.1016/j.ddmec.2010.07.001

Source DB:  PubMed          Journal:  Drug Discov Today Dis Mech        ISSN： 1740-6765


  56 in total

1.  Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors.

Authors:  J A Pitcher; J Inglese; J B Higgins; J L Arriza; P J Casey; C Kim; J L Benovic; M M Kwatra; M G Caron; R J Lefkowitz
Journal:  Science       Date:  1992-08-28       Impact factor: 47.728

Review 2.  Rationally designed peptide regulators of protein kinase C.

Authors:  Eric N Churchill; Nir Qvit; Daria Mochly-Rosen
Journal:  Trends Endocrinol Metab       Date:  2008-12-04       Impact factor: 12.015

3.  The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence.

Authors:  D Grabs; V I Slepnev; Z Songyang; C David; M Lynch; L C Cantley; P De Camilli
Journal:  J Biol Chem       Date:  1997-05-16       Impact factor: 5.157

4.  PKC-beta is not necessary for cardiac hypertrophy.

Authors:  B B Roman; D L Geenen; M Leitges; P M Buttrick
Journal:  Am J Physiol Heart Circ Physiol       Date:  2001-05       Impact factor: 4.733

5.  Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C.

Authors:  E G Stebbins; D Mochly-Rosen
Journal:  J Biol Chem       Date:  2001-05-31       Impact factor: 5.157

6.  Protein kinase C epsilon mediates angiotensin II-induced activation of beta1-integrins in cardiac fibroblasts.

Authors:  Philipp Stawowy; Christian Margeta; Florian Blaschke; Carsten Lindschau; Chantel Spencer-Hänsch; Michael Leitges; Giuseppe Biagini; Eckart Fleck; Kristof Graf
Journal:  Cardiovasc Res       Date:  2005-04-07       Impact factor: 10.787

7.  C2 region-derived peptides inhibit translocation and function of beta protein kinase C in vivo.

Authors:  D Ron; J Luo; D Mochly-Rosen
Journal:  J Biol Chem       Date:  1995-10-13       Impact factor: 5.157

8.  Additive protection of the ischemic heart ex vivo by combined treatment with delta-protein kinase C inhibitor and epsilon-protein kinase C activator.

Authors:  Koichi Inagaki; Harvey S Hahn; Gerald W Dorn; Daria Mochly-Rosen
Journal:  Circulation       Date:  2003-07-14       Impact factor: 29.690

9.  Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane.

Authors:  A S Kraft; W B Anderson
Journal:  Nature       Date:  1983 Feb 17-23       Impact factor: 49.962

Review 10.  Protein kinase C: a target for anticancer drugs?

Authors:  H J Mackay; C J Twelves
Journal:  Endocr Relat Cancer       Date:  2003-09       Impact factor: 5.678
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  20 in total

1.  The many hats of protein kinase Cδ: one enzyme with many functions.

Authors:  Nir Qvit; Daria Mochly-Rosen
Journal:  Biochem Soc Trans       Date:  2014-12       Impact factor: 5.407

2.  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) phosphorylation by protein kinase Cδ (PKCδ) inhibits mitochondria elimination by lysosomal-like structures following ischemia and reoxygenation-induced injury.

Authors:  Gouri Yogalingam; Sunhee Hwang; Julio C B Ferreira; Daria Mochly-Rosen
Journal:  J Biol Chem       Date:  2013-05-07       Impact factor: 5.157

3.  Pronase E-Based Generation of Fluorescent Peptide Fragments: Tracking Intracellular Peptide Fate in Single Cells.

Authors:  Emilie R Mainz; Nicholas C Dobes; Nancy L Allbritton
Journal:  Anal Chem       Date:  2015-07-24       Impact factor: 6.986

4.  Protein kinase Cɛ inhibition restores megakaryocytic differentiation of hematopoietic progenitors from primary myelofibrosis patients.

Authors:  E Masselli; C Carubbi; G Gobbi; P Mirandola; D Galli; S Martini; S Bonomini; M Crugnola; L Craviotto; F Aversa; M Vitale
Journal:  Leukemia       Date:  2015-06-19       Impact factor: 11.528

5.  A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.

Authors:  Xin Qi; Nir Qvit; Yu-Chin Su; Daria Mochly-Rosen
Journal:  J Cell Sci       Date:  2012-12-13       Impact factor: 5.285

Review 6.  Peptides and peptidomimetics as regulators of protein-protein interactions.

Authors:  Anna D Cunningham; Nir Qvit; Daria Mochly-Rosen
Journal:  Curr Opin Struct Biol       Date:  2017-01-04       Impact factor: 6.809

Review 7.  Protein Kinase C as Regulator of Vascular Smooth Muscle Function and Potential Target in Vascular Disorders.

Authors:  H C Ringvold; R A Khalil
Journal:  Adv Pharmacol       Date:  2016-07-18

8.  Sirtuin 1 represses PKC-ζ activity through regulating interplay of acetylation and phosphorylation in cardiac hypertrophy.

Authors:  Jingyan Li; Junying Huang; Jing Lu; Zhen Guo; Zhuoming Li; Hui Gao; Panxia Wang; Wenwei Luo; Sidong Cai; Yuehuai Hu; Kaiteng Guo; Luping Wang; Zhenzhen Li; Minghui Wang; Xiaolei Zhang; Peiqing Liu
Journal:  Br J Pharmacol       Date:  2018-12-09       Impact factor: 8.739

9.  PKCε mediates resistin-induced NADPH oxidase activation and inflammation leading to smooth muscle cell dysfunction and intimal hyperplasia.

Authors:  Gayatri Raghuraman; Mary C Zuniga; Hai Yuan; Wei Zhou
Journal:  Atherosclerosis       Date:  2016-08-20       Impact factor: 5.162

10.  Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Protein-Protein Interaction Inhibitor Reveals a Non-catalytic Role for GAPDH Oligomerization in Cell Death.

Authors:  Nir Qvit; Amit U Joshi; Anna D Cunningham; Julio C B Ferreira; Daria Mochly-Rosen
Journal:  J Biol Chem       Date:  2016-04-27       Impact factor: 5.157
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