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Literature DB >> 2115127

Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Krüppel.

N Kato¹, K Shimotohno, D VanLeeuwen, M Cohen.

Abstract

RNA transcripts of the HERV-R (ERV3) human provirus that are abundant in placenta but absent in choriocarcinoma contain nonproviral genomic sequences at their 3' ends. We report here the isolation of cDNA clones of these genomic sequences. The transcripts encode a Krüppel-related zinc finger protein consisting of a unique leader region and more than 12 28-amino-acid finger motifs.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1990 PMID： 2115127 PMCID： PMC361000 DOI： 10.1128/mcb.10.8.4401-4405.1990

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

22 in total

1. A gene that encodes a protein consisting solely of zinc finger domains is preferentially expressed in transformed mouse cells.

Authors: M Ernoult-Lange; M Kress; D Hamer
Journal: Mol Cell Biol Date: 1990-01 Impact factor: 4.272

2. Drosophila Krüppel gene product produced in a baculovirus expression system is a nuclear phosphoprotein that binds to DNA.

Authors: R Ollo; T Maniatis
Journal: Proc Natl Acad Sci U S A Date: 1987-08 Impact factor: 11.205

3. The human genome contains hundreds of genes coding for finger proteins of the Krüppel type.

Authors: E J Bellefroid; P J Lecocq; A Benhida; D A Poncelet; A Belayew; J A Martial
Journal: DNA Date: 1989 Jul-Aug

Review 4. Zinc fingers: gilt by association.

Authors: R M Evans; S M Hollenberg
Journal: Cell Date: 1988-01-15 Impact factor: 41.582

5. Sequence-specific DNA-binding activities of the gap proteins encoded by hunchback and Krüppel in Drosophila.

Authors: D Stanojević; T Hoey; M Levine
Journal: Nature Date: 1989-09-28 Impact factor: 49.962

6. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus.

Authors: K M Call; T Glaser; C Y Ito; A J Buckler; J Pelletier; D A Haber; E A Rose; A Kral; H Yeger; W H Lewis
Journal: Cell Date: 1990-02-09 Impact factor: 41.582

7. Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping.

Authors: M Gessler; A Poustka; W Cavenee; R L Neve; S H Orkin; G A Bruns
Journal: Nature Date: 1990-02-22 Impact factor: 49.962

8. Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines.

Authors: K Morishita; D S Parker; M L Mucenski; N A Jenkins; N G Copeland; J N Ihle
Journal: Cell Date: 1988-09-09 Impact factor: 41.582

9. The GLI gene is a member of the Kruppel family of zinc finger proteins.

Authors: K W Kinzler; J M Ruppert; S H Bigner; B Vogelstein
Journal: Nature Date: 1988-03-24 Impact factor: 49.962

10. The primary structure of the murine multifinger gene mKr2 and its specific expression in developing and adult neurons.

Authors: K Chowdhury; G Dressler; G Breier; U Deutsch; P Gruss
Journal: EMBO J Date: 1988-05 Impact factor: 11.598

16 in total

10. Characterization and genomic mapping of the ZNF80 locus: expression of this zinc-finger gene is driven by a solitary LTR of ERV9 endogenous retroviral family.

Authors: A Di Cristofano; M Strazzullo; L Longo; G La Mantia
Journal: Nucleic Acids Res Date: 1995-08-11 Impact factor: 16.971

Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Krüppel.

1. A gene that encodes a protein consisting solely of zinc finger domains is preferentially expressed in transformed mouse cells.

2. Drosophila Krüppel gene product produced in a baculovirus expression system is a nuclear phosphoprotein that binds to DNA.

3. The human genome contains hundreds of genes coding for finger proteins of the Krüppel type.

Review 4. Zinc fingers: gilt by association.

5. Sequence-specific DNA-binding activities of the gap proteins encoded by hunchback and Krüppel in Drosophila.

6. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus.

7. Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping.

8. Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines.

9. The GLI gene is a member of the Kruppel family of zinc finger proteins.

10. The primary structure of the murine multifinger gene mKr2 and its specific expression in developing and adult neurons.

1. The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.

2. Expression cloning of a novel zinc finger protein that binds to the c-fos serum response element.

3. New nucleotide sequence data on the EMBL File Server.

4. Evolutionary selection against change in many Alu repeat sequences interspersed through primate genomes.

5. The KUP gene, located on human chromosome 14, encodes a protein with two distant zinc fingers.

Review 6. Evolution and biological significance of human retroelements.

7. Molecular characterization and placental expression of HERV-W, a new human endogenous retrovirus family.

8. Exonization of the LTR transposable elements in human genome.

9. Splicing of a human endogenous retrovirus to a novel phospholipase A2 related gene.

10. Characterization and genomic mapping of the ZNF80 locus: expression of this zinc-finger gene is driven by a solitary LTR of ERV9 endogenous retroviral family.