Literature DB >> 21147163

Perfusion deficit to cholinergic challenge in veterans with Gulf War Illness.

Peiying Liu1, Sina Aslan, Xiufeng Li, David M Buhner, Jeffrey S Spence, Richard W Briggs, Robert W Haley, Hanzhang Lu.   

Abstract

A highly plausible etiology for Gulf War Illness (GWI) is that the neural damage and cognitive deficits are associated with excessive exposure to cholinesterase-inhibiting cholinergic stimulants. Our previous SPECT study provided strong indication that cerebral blood flow (CBF) in veterans with GWI may be different from those of unaffected control veterans. The present study confirmed and extended previous findings that patients with GWI have abnormal response to an inhibitory cholinergic challenge, physostigmine infusion, when compared to age-gender-education matched control veterans. The MRI-based arterial spin labeling (ASL) and phase-contrast techniques have several key advantages over SPECT, including shorter experiment duration, complete non-invasiveness, and higher spatial and temporal resolutions, and therefore may provide a cost-effective biomarker for characterization of GWI.
Copyright © 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 21147163      PMCID： PMC3049842          DOI： 10.1016/j.neuro.2010.12.004

Source DB:  PubMed          Journal:  Neurotoxicology        ISSN： 0161-813X            Impact factor:   4.294


  14 in total

1.  Vestibular dysfunction in Gulf War syndrome.

Authors:  P S Roland; R W Haley; W Yellin; K Owens; A G Shoup
Journal:  Otolaryngol Head Neck Surg       Date:  2000-03       Impact factor: 3.497

2.  Use of structural equation modeling to test the construct validity of a case definition of Gulf War syndrome: invariance over developmental and validation samples, service branches and publicity.

Authors:  R W Haley; G D Luk; F Petty
Journal:  Psychiatry Res       Date:  2001-06-01       Impact factor: 3.222

3.  The long-term influence of low-level sarin exposure on behavioral and neurophysiological functions in rats.

Authors:  J Kassa; M Koupilová; J Herink; J Vachek
Journal:  Acta Medica (Hradec Kralove)       Date:  2001

4.  Evidence for a deployment-related Gulf War syndrome by factor analysis.

Authors:  Han K Kang; Clare M Mahan; Kyung Y Lee; Frances M Murphy; Samuel J Simmens; Heather A Young; Paul H Levine
Journal:  Arch Environ Health       Date:  2002 Jan-Feb

5.  Abnormal brain response to cholinergic challenge in chronic encephalopathy from the 1991 Gulf War.

Authors:  Robert W Haley; Jeffrey S Spence; Patrick S Carmack; Richard F Gunst; William R Schucany; Frederick Petty; Michael D Devous; Frederick J Bonte; Madhukar H Trivedi
Journal:  Psychiatry Res       Date:  2009-02-20       Impact factor: 3.222

6.  Chronic multisymptom illness affecting Air Force veterans of the Gulf War.

Authors:  K Fukuda; R Nisenbaum; G Stewart; W W Thompson; L Robin; R M Washko; D L Noah; D H Barrett; B Randall; B L Herwaldt; A C Mawle; W C Reeves
Journal:  JAMA       Date:  1998-09-16       Impact factor: 56.272

7.  Response of rats to low levels of sarin.

Authors:  Rogene F Henderson; Edward B Barr; Walter B Blackwell; Connie R Clark; Carole A Conn; Roma Kalra; Thomas H March; Mohan L Sopori; Yohannes Tesfaigzi; Margaret G Ménache; Deborah C Mash
Journal:  Toxicol Appl Pharmacol       Date:  2002-10-15       Impact factor: 4.219

8.  Sarin produces delayed cardiac and central autonomic changes.

Authors:  Mariana Morris; Mary P Key; Vera Farah
Journal:  Exp Neurol       Date:  2006-09-25       Impact factor: 5.330

9.  Is there a Gulf War Syndrome? Searching for syndromes by factor analysis of symptoms.

Authors:  R W Haley; T L Kurt; J Hom
Journal:  JAMA       Date:  1997-01-15       Impact factor: 56.272

10.  Response of F344 rats to inhalation of subclinical levels of sarin: exploring potential causes of Gulf War illness.

Authors:  R F Henderson; E B Barr; W B Blackwell; C R Clark; C A Conn; R Kalra; T H March; M L Sopori; Y Tesfaigzi; M G Ménache; D C Mash; K Dokladny; W Kozak; A Kozak; M Wachulec; K Rudolph; M J Kluger; S P Singh; S Razani-Boroujerdi; R J Langley
Journal:  Toxicol Ind Health       Date:  2001-06       Impact factor: 2.273
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  15 in total

1.  Subcortical brain atrophy in Gulf War Illness.

Authors:  Peka Christova; Lisa M James; Brian E Engdahl; Scott M Lewis; Adam F Carpenter; Apostolos P Georgopoulos
Journal:  Exp Brain Res       Date:  2017-06-20       Impact factor: 1.972

2.  Visual event-related potentials as markers of hyperarousal in Gulf War illness: evidence against a stress-related etiology.

Authors:  Gail D Tillman; Clifford S Calley; Timothy A Green; Virginia I Buhl; Melanie M Biggs; Jeffrey S Spence; Richard W Briggs; Robert W Haley; Michael A Kraut; John Hart
Journal:  Psychiatry Res       Date:  2012-11-11       Impact factor: 3.222

Review 3.  Severe life stress and oxidative stress in the brain: from animal models to human pathology.

Authors:  Stefania Schiavone; Vincent Jaquet; Luigia Trabace; Karl-Heinz Krause
Journal:  Antioxid Redox Signal       Date:  2012-08-06       Impact factor: 8.401

4.  Hippocampal dysfunction in Gulf War veterans: investigation with ASL perfusion MR imaging and physostigmine challenge.

Authors:  Xiufeng Li; Jeffrey S Spence; David M Buhner; John Hart; C Munro Cullum; Melanie M Biggs; Andrea L Hester; Timothy N Odegard; Patrick S Carmack; Richard W Briggs; Robert W Haley
Journal:  Radiology       Date:  2011-09-13       Impact factor: 11.105

5.  FMRI reveals abnormal central processing of sensory and pain stimuli in ill Gulf War veterans.

Authors:  Kaundinya Gopinath; Parina Gandhi; Aman Goyal; Lei Jiang; Yan Fang; Luo Ouyang; Sandeepkumar Ganji; David Buhner; Wendy Ringe; Jeffrey Spence; Melanie Biggs; Richard Briggs; Robert Haley
Journal:  Neurotoxicology       Date:  2012-02-04       Impact factor: 4.294

6.  Effects of low-level sarin and cyclosarin exposure on hippocampal subfields in Gulf War Veterans.

Authors:  Linda L Chao; Stephen Kriger; Shannon Buckley; Peter Ng; Susanne G Mueller
Journal:  Neurotoxicology       Date:  2014-07-21       Impact factor: 4.294

7.  Lipidomic profiling of phosphocholine-containing brain lipids in mice with sensorimotor deficits and anxiety-like features after exposure to Gulf War agents.

Authors:  Laila Abdullah; James E Evans; Alex Bishop; Jon M Reed; Gogce Crynen; John Phillips; Robert Pelot; Myles A Mullan; Austin Ferro; Christopher M Mullan; Michael J Mullan; Ghania Ait-Ghezala; Fiona C Crawford
Journal:  Neuromolecular Med       Date:  2012-07-14       Impact factor: 3.843

Review 8.  Gulf War Illness: Mechanisms Underlying Brain Dysfunction and Promising Therapeutic Strategies.

Authors:  Brandon Dickey; Leelavathi N Madhu; Ashok K Shetty
Journal:  Pharmacol Ther       Date:  2020-10-24       Impact factor: 12.310

9.  Enhanced Cholinergic Activity Improves Cerebral Blood Flow during Orthostatic Stress.

Authors:  Jorge M Serrador; Roy Freeman
Journal:  Front Neurol       Date:  2017-03-20       Impact factor: 4.003

Review 10.  Recent research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: Effects of toxicant exposures during deployment.

Authors:  Roberta F White; Lea Steele; James P O'Callaghan; Kimberly Sullivan; James H Binns; Beatrice A Golomb; Floyd E Bloom; James A Bunker; Fiona Crawford; Joel C Graves; Anthony Hardie; Nancy Klimas; Marguerite Knox; William J Meggs; Jack Melling; Martin A Philbert; Rachel Grashow
Journal:  Cortex       Date:  2015-09-25       Impact factor: 4.027
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