OBJECTIVE: To examine exercise capacity in youth with Crohn's disease (CD) and ulcerative colitis (UC). STUDY DESIGN: Eleven males and eight females with CD and six males and four females with UC participated. Patients performed standard exercise tests to assess peak power (PP) and mean power (MP) and peak aerobic mechanical power (W(peak)) and peak oxygen uptake (VO(2peak)). Fitness variables were compared with reference data and also correlated with relevant clinical outcomes. RESULTS: Pediatric patients with inflammatory bowel disease had lower PP (∼90% of predicted), MP (∼88% of predicted), W(peak) (∼91% of predicted), and VO(2peak) (∼75% of predicted) compared with reference values. When patients with CD or UC were compared separately to reference values, W(peak) was significantly lower only in the CD group. No statistically significant correlations were found between any exercise variables and disease duration (r = 0.01 to 0.14, P = .47 to .95) or disease activity (r = -0.19 to -0.31, P = .11 to .38), measured by pediatric CD activity index or pediatric ulcerative colitis activity index. After controlling for chronological age, recent hemoglobin levels were significantly correlated with PP (r = 0.45, P = .049), MP (r = 0.63, P = .003), VO(2peak) (r = 0.62, P = .004), and W(peak) (r = 0.70, P = .001). CONCLUSIONS: Pediatric patients with inflammatory bowel disease exhibit impaired aerobic and anaerobic exercise capacity compared with reference values.
OBJECTIVE: To examine exercise capacity in youth with Crohn's disease (CD) and ulcerative colitis (UC). STUDY DESIGN: Eleven males and eight females with CD and six males and four females with UC participated. Patients performed standard exercise tests to assess peak power (PP) and mean power (MP) and peak aerobic mechanical power (W(peak)) and peak oxygen uptake (VO(2peak)). Fitness variables were compared with reference data and also correlated with relevant clinical outcomes. RESULTS: Pediatric patients with inflammatory bowel disease had lower PP (∼90% of predicted), MP (∼88% of predicted), W(peak) (∼91% of predicted), and VO(2peak) (∼75% of predicted) compared with reference values. When patients with CD or UC were compared separately to reference values, W(peak) was significantly lower only in the CD group. No statistically significant correlations were found between any exercise variables and disease duration (r = 0.01 to 0.14, P = .47 to .95) or disease activity (r = -0.19 to -0.31, P = .11 to .38), measured by pediatric CD activity index or pediatric ulcerative colitis activity index. After controlling for chronological age, recent hemoglobin levels were significantly correlated with PP (r = 0.45, P = .049), MP (r = 0.63, P = .003), VO(2peak) (r = 0.62, P = .004), and W(peak) (r = 0.70, P = .001). CONCLUSIONS: Pediatric patients with inflammatory bowel disease exhibit impaired aerobic and anaerobic exercise capacity compared with reference values.
Authors: Patricia D Jones; Michael D Kappelman; Christopher F Martin; Wenli Chen; Robert S Sandler; Millie D Long Journal: Inflamm Bowel Dis Date: 2015-05 Impact factor: 5.325
Authors: Margaux J Barnes; Mary K Lynch; Molly D Lisenby; Traci Jester; Jeanine Maclin; Taylor Knight; Gordon Fisher; Barbara Gower Journal: J Pediatr Gastroenterol Nutr Date: 2019-03 Impact factor: 2.839
Authors: J M Otto; A F O'Doherty; P J Hennis; K Mitchell; J S Pate; J A Cooper; M P W Grocott; H E Montgomery Journal: Int J Colorectal Dis Date: 2012-07-29 Impact factor: 2.571
Authors: Bun Kim; Jisuk Chae; Eun Hye Kim; Hyuk In Yang; Jae Hee Cheon; Tae Il Kim; Won Ho Kim; Justin Y Jeon; Soo Jung Park Journal: Medicine (Baltimore) Date: 2021-07-09 Impact factor: 1.817
Authors: Philomine A van Pelt; Tim Takken; Marco van Brussel; Mirjam de Witte; Aike A Kruize; Nico M Wulffraat Journal: Pediatr Rheumatol Online J Date: 2012-08-20 Impact factor: 3.054
Authors: Philomien A van Pelt; Tim Takken; Marco van Brussel; Inge de Witte; Aike A Kruize; Nico M Wulffraat Journal: Pediatr Rheumatol Online J Date: 2012-08-27 Impact factor: 3.054