BACKGROUND: We performed an evaluation of antimicrobial guidelines for patients with surgical sepsis. METHODS: The purpose of this study was to validate current empiric antibiotic recommendations in our sepsis protocol based on the suspected site of infection. The primary objective was to assess the appropriateness of empiric antibiotic recommendations and to determine if initial empiric antibiotics provided adequate coverage compared with sensitivity data (accuracy). Secondary end points included antibiotic protocol compliance, intensive care unit (ICU)-free days, and mortality. RESULTS: Appropriate antibiotics were prescribed in 82% of patients. Of the culture-positive patients, 72% received accurate antibiotics. ICU-free days were greater for patients in the compliant group (14.5 vs 8.4; P = .014). Hospital mortality was greater in patients who were noncompliant with protocol recommendations (22% vs 17%; P = .44). CONCLUSIONS: Our current antibiotic guidelines provide appropriate and accurate antimicrobial coverage. Noncompliance with the antibiotic protocol resulted in fewer ICU-free days and increased hospital mortality in surgical sepsis patients.
BACKGROUND: We performed an evaluation of antimicrobial guidelines for patients with surgical sepsis. METHODS: The purpose of this study was to validate current empiric antibiotic recommendations in our sepsis protocol based on the suspected site of infection. The primary objective was to assess the appropriateness of empiric antibiotic recommendations and to determine if initial empiric antibiotics provided adequate coverage compared with sensitivity data (accuracy). Secondary end points included antibiotic protocol compliance, intensive care unit (ICU)-free days, and mortality. RESULTS: Appropriate antibiotics were prescribed in 82% of patients. Of the culture-positive patients, 72% received accurate antibiotics. ICU-free days were greater for patients in the compliant group (14.5 vs 8.4; P = .014). Hospital mortality was greater in patients who were noncompliant with protocol recommendations (22% vs 17%; P = .44). CONCLUSIONS: Our current antibiotic guidelines provide appropriate and accurate antimicrobial coverage. Noncompliance with the antibiotic protocol resulted in fewer ICU-free days and increased hospital mortality in surgical sepsispatients.
Authors: Julie A Stortz; Tyler J Murphy; Steven L Raymond; Juan C Mira; Ricardo Ungaro; Marvin L Dirain; Dina C Nacionales; Tyler J Loftus; Zhongkai Wang; Tezcan Ozrazgat-Baslanti; Gabriela L Ghita; Babette A Brumback; Alicia M Mohr; Azra Bihorac; Philip A Efron; Lyle L Moldawer; Frederick A Moore; Scott C Brakenridge Journal: Shock Date: 2018-03 Impact factor: 3.454
Authors: Camille G Apple; Lauren S Kelly; Kolenkode B Kannan; Ricardo F Ungaro; Frederick A Moore; Scott C Brakenridge; Lyle L Moldawer; Philip A Efron; Alicia M Mohr Journal: Surg Infect (Larchmt) Date: 2021-12-24 Impact factor: 1.853
Authors: McKenzie K Hollen; Julie A Stortz; Dijoia Darden; Marvin L Dirain; Dina C Nacionales; Russell B Hawkins; Michael C Cox; Maria-Cecilia Lopez; Jaimar C Rincon; Ricardo Ungaro; Zhongkai Wang; Quran Wu; Babette Brumback; Marie-Pierre L Gauthier; Michael Kladde; Christiaan Leeuwenburgh; Mark Segal; Azra Bihorac; Scott Brakenridge; Frederick A Moore; Henry V Baker; Alicia M Mohr; Lyle L Moldawer; Philip A Efron Journal: Crit Care Date: 2019-11-13 Impact factor: 9.097
Authors: Philip A Efron; Dijoia B Darden; Zhongkai Wang; Dina C Nacionales; Maria-Cecilia Lopez; Russell B Hawkins; Michael C Cox; Jaimar C Rincon; Ricardo Ungaro; Marvin L Dirain; Gabriela L Ghita; Tianmeng Chen; Timothy R Billiar; Matthew J Delano; Christiaan Leeuwenburgh; Azra Bihorac; Scott C Brakenridge; Frederick A Moore; Alicia M Mohr; Ronald G Tompkins; Babette A Brumback; Henry V Baker; Gilbert R Upchurch; Lyle L Moldawer Journal: FASEB J Date: 2020-11-02 Impact factor: 5.834