OBJECTIVE: Obsessive-compulsive disorder (OCD) is phenomenologically heterogeneous, and findings of underlying structure classification based on symptom grouping have been ambiguous to date. Variable-centered approaches, primarily factor analysis, have been used to identify homogeneous groups of symptoms; but person-centered latent methods have seen little use. This study was designed to uncover sets of homogeneous groupings within 1611 individuals with OCD based on symptoms. METHOD: Latent class analysis models using 61 obsessive-compulsive symptoms collected from the Yale-Brown Obsessive-Compulsive Scale were fit. Relationships between latent class membership and treatment response, sex, symptom severity, and comorbid tic disorders were tested for relationship to class membership. RESULTS: Latent class analysis models of best fit yielded 3 classes. Classes differed only in frequency of symptom endorsement. Classes with higher symptom endorsement were associated with earlier age of onset, being male, higher Yale-Brown Obsessive-Compulsive Scale symptom severity scores, and comorbid tic disorders. There were no differences in treatment response between classes. CONCLUSIONS: These results provide support for the validity of a single underlying latent OCD construct, in addition to the distinct symptom factors identified previously via factor analyses.
OBJECTIVE:Obsessive-compulsive disorder (OCD) is phenomenologically heterogeneous, and findings of underlying structure classification based on symptom grouping have been ambiguous to date. Variable-centered approaches, primarily factor analysis, have been used to identify homogeneous groups of symptoms; but person-centered latent methods have seen little use. This study was designed to uncover sets of homogeneous groupings within 1611 individuals with OCD based on symptoms. METHOD: Latent class analysis models using 61 obsessive-compulsive symptoms collected from the Yale-Brown Obsessive-Compulsive Scale were fit. Relationships between latent class membership and treatment response, sex, symptom severity, and comorbid tic disorders were tested for relationship to class membership. RESULTS: Latent class analysis models of best fit yielded 3 classes. Classes differed only in frequency of symptom endorsement. Classes with higher symptom endorsement were associated with earlier age of onset, being male, higher Yale-Brown Obsessive-Compulsive Scale symptom severity scores, and comorbid tic disorders. There were no differences in treatment response between classes. CONCLUSIONS: These results provide support for the validity of a single underlying latent OCD construct, in addition to the distinct symptom factors identified previously via factor analyses.
Authors: R J Neuman; R D Todd; A C Heath; W Reich; J J Hudziak; K K Bucholz; P A Madden; H Begleiter; B Porjesz; S Kuperman; V Hesselbrock; T Reich Journal: J Am Acad Child Adolesc Psychiatry Date: 1999-01 Impact factor: 8.829
Authors: J J Hudziak; A C Heath; P F Madden; W Reich; K K Bucholz; W Slutske; L J Bierut; R J Neuman; R D Todd Journal: J Am Acad Child Adolesc Psychiatry Date: 1998-08 Impact factor: 8.829
Authors: W K Goodman; L H Price; S A Rasmussen; C Mazure; R L Fleischmann; C L Hill; G R Heninger; D S Charney Journal: Arch Gen Psychiatry Date: 1989-11
Authors: Mieke Decuyper; Olivier F Colins; Barbara De Clercq; Robert Vermeiren; Eric Broekaert; Patricia Bijttebier; Annelore Roose; Filip De Fruyt Journal: Child Psychiatry Hum Dev Date: 2013-04
Authors: M E Hirschtritt; S M Darrow; C Illmann; L Osiecki; M Grados; P Sandor; Y Dion; R A King; D Pauls; C L Budman; D C Cath; E Greenberg; G J Lyon; D Yu; L M McGrath; W M McMahon; P C Lee; K L Delucchi; J M Scharf; C A Mathews Journal: Psychol Med Date: 2017-06-27 Impact factor: 7.723