Literature DB >> 21145450

Insulin signaling: inositol phosphates get into the Akt.

Brendan D Manning1.   

Abstract

An acute but transient response to insulin is essential for glucose homeostasis in mammals. Chakraborty et al. (2010) uncover a new feedback mechanism regulating insulin signaling. They show that the inositol pyrophosphate IP7, which is produced in response to insulin, inhibits the Akt kinase, a primary effector of insulin signaling.
Copyright © 2010 Elsevier Inc. All rights reserved.

Entities:  

Year:  2010        PMID： 21145450      PMCID： PMC3693466          DOI： 10.1016/j.cell.2010.11.040

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  9 in total

Review 1.  Critical nodes in signalling pathways: insights into insulin action.

Authors:  Cullen M Taniguchi; Brice Emanuelli; C Ronald Kahn
Journal:  Nat Rev Mol Cell Biol       Date:  2006-02       Impact factor: 94.444

Review 2.  Restraining PI3K: mTOR signalling goes back to the membrane.

Authors:  Laura S Harrington; Greg M Findlay; Richard F Lamb
Journal:  Trends Biochem Sci       Date:  2005-01       Impact factor: 13.807

Review 3.  Role of Akt/protein kinase B in metabolism.

Authors:  Eileen L Whiteman; Han Cho; Morris J Birnbaum
Journal:  Trends Endocrinol Metab       Date:  2002-12       Impact factor: 12.015

4.  Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells.

Authors:  Christopher Illies; Jesper Gromada; Roberta Fiume; Barbara Leibiger; Jia Yu; Kirstine Juhl; Shao-Nian Yang; Deb K Barma; John R Falck; Adolfo Saiardi; Christopher J Barker; Per-Olof Berggren
Journal:  Science       Date:  2007-11-23       Impact factor: 47.728

5.  Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions.

Authors:  Hongbo R Luo; Yi Elaine Huang; Jianmeng C Chen; Adolfo Saiardi; Miho Iijima; Keqiang Ye; Yunfei Huang; Eiichiro Nagata; Peter Devreotes; Solomon H Snyder
Journal:  Cell       Date:  2003-09-05       Impact factor: 41.582

Review 6.  Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.

Authors:  Adilson Guilherme; Joseph V Virbasius; Vishwajeet Puri; Michael P Czech
Journal:  Nat Rev Mol Cell Biol       Date:  2008-05       Impact factor: 94.444

7.  Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity.

Authors:  Sung Hee Um; Francesca Frigerio; Mitsuhiro Watanabe; Frédéric Picard; Manel Joaquin; Melanie Sticker; Stefano Fumagalli; Peter R Allegrini; Sara C Kozma; Johan Auwerx; George Thomas
Journal:  Nature       Date:  2004-08-11       Impact factor: 49.962

8.  Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis.

Authors:  Rashna Bhandari; Krishna R Juluri; Adam C Resnick; Solomon H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-11       Impact factor: 11.205

Review 9.  AKT/PKB signaling: navigating downstream.

Authors:  Brendan D Manning; Lewis C Cantley
Journal:  Cell       Date:  2007-06-29       Impact factor: 41.582
  9 in total
  8 in total

1.  High-mobility group A1 proteins enhance the expression of the oncogenic miR-222 in lung cancer cells.

Authors:  Yunzhi Zhang; Teng Ma; Shuping Yang; Mingying Xia; Jing Xu; Haijia An; Yajun Yang; Shilin Li
Journal:  Mol Cell Biochem       Date:  2011-06-09       Impact factor: 3.396

Review 2.  The inositol pyrophosphate pathway in health and diseases.

Authors:  Anutosh Chakraborty
Journal:  Biol Rev Camb Philos Soc       Date:  2017-12-27

3.  Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes.

Authors:  Eun Suk Song; HyeIn Jang; Hou-Fu Guo; Maria A Juliano; Luiz Juliano; Andrew J Morris; Emilia Galperin; David W Rodgers; Louis B Hersh
Journal:  Proc Natl Acad Sci U S A       Date:  2017-03-21       Impact factor: 11.205

Review 4.  Lipid and Protein Co-Regulation of PI3K Effectors Akt and Itk in Lymphocytes.

Authors:  Xinxin Wang; Leonard Benjamin Hills; Yina Hsing Huang
Journal:  Front Immunol       Date:  2015-03-13       Impact factor: 7.561

Review 5.  Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes.

Authors:  Richard Wa Mackenzie; Bradley T Elliott
Journal:  Diabetes Metab Syndr Obes       Date:  2014-02-13       Impact factor: 3.168

Review 6.  Role of Inositols and Inositol Phosphates in Energy Metabolism.

Authors:  Saimai Chatree; Nanthaphop Thongmaen; Kwanchanit Tantivejkul; Chantacha Sitticharoon; Ivana Vucenik
Journal:  Molecules       Date:  2020-11-01       Impact factor: 4.411

7.  Preliminary Evidence for Adipocytokine Signals in Skeletal Muscle Glucose Uptake.

Authors:  Akihiro Kudoh; Hiroaki Satoh; Hiroyuki Hirai; Tsuyoshi Watanabe; Michio Shimabukuro
Journal:  Front Endocrinol (Lausanne)       Date:  2018-06-07       Impact factor: 5.555

8.  Differential Diabetogenic Effect of Pitavastatin and Rosuvastatin, in vitro and in vivo.

Authors:  Yongin Cho; Hyangkyu Lee; Hyun Ki Park; Eun Yeong Choe; Hye Jin Wang; Ryeong-Hyeon Kim; Youjin Kim; Eun Seok Kang
Journal:  J Atheroscler Thromb       Date:  2019-09-13       Impact factor: 4.928
  8 in total

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