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Literature DB >> 21144739

The folding of single domain proteins--have we reached a consensus?

Abstract

Rather than stressing the most recent advances in the field, this review highlights the fundamental topics where disagreement remains and where adequate experimental data are lacking. These topics include properties of the denatured state and the role of residual structure, the nature of the fundamental steps and barriers, the extent of pathway heterogeneity and non-native interactions, recent comparisons between theory and experiment, and finally, dynamical properties of the folding reaction.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Proteins

Year: 2010 PMID： 21144739 PMCID： PMC3039110 DOI： 10.1016/j.sbi.2010.11.002

Source DB: PubMed Journal: Curr Opin Struct Biol ISSN： 0959-440X Impact factor: 6.809

192 in total

1. Transition state heterogeneity in GCN4 coiled coil folding studied by using multisite mutations and crosslinking.

Authors: L B Moran; J P Schneider; A Kentsis; G A Reddy; T R Sosnick
Journal: Proc Natl Acad Sci U S A Date: 1999-09-14 Impact factor: 11.205

2. A simple model for calculating the kinetics of protein folding from three-dimensional structures.

Authors: V Muñoz; W A Eaton
Journal: Proc Natl Acad Sci U S A Date: 1999-09-28 Impact factor: 11.205

3. Differences in the folding transition state of ubiquitin indicated by phi and psi analyses.

Authors: Tobin R Sosnick; Robin S Dothager; Bryan A Krantz
Journal: Proc Natl Acad Sci U S A Date: 2004-12-02 Impact factor: 11.205

4. Structural examination of phi-value analysis in protein folding.

Authors: Hanqiao Feng; Ngoc-Diep Vu; Zheng Zhou; Yawen Bai
Journal: Biochemistry Date: 2004-11-16 Impact factor: 3.162

5. Protein folding: the stepwise assembly of foldon units.

Authors: Haripada Maity; Mita Maity; Mallela M G Krishna; Leland Mayne; S Walter Englander
Journal: Proc Natl Acad Sci U S A Date: 2005-03-17 Impact factor: 11.205

6. Specific collapse followed by slow hydrogen-bond formation of beta-sheet in the folding of single-chain monellin.

Authors: Tetsunari Kimura; Takanori Uzawa; Koichiro Ishimori; Isao Morishima; Satoshi Takahashi; Takashi Konno; Shuji Akiyama; Tetsuro Fujisawa
Journal: Proc Natl Acad Sci U S A Date: 2005-02-14 Impact factor: 11.205

7. Scanning malleable transition state ensembles: comparing theory and experiment for folding protein U1A.

Authors: Tongye Shen; Christoph P Hofmann; Mikael Oliveberg; Peter G Wolynes
Journal: Biochemistry Date: 2005-05-03 Impact factor: 3.162

8. Ubiquitin folds through a highly polarized transition state.

Authors: Heather M Went; Sophie E Jackson
Journal: Protein Eng Des Sel Date: 2005-04-27 Impact factor: 1.650

9. Desolvation is a likely origin of robust enthalpic barriers to protein folding.

Authors: Zhirong Liu; Hue Sun Chan
Journal: J Mol Biol Date: 2005-04-15 Impact factor: 5.469

10. Barrier-limited, microsecond folding of a stable protein measured with hydrogen exchange: Implications for downhill folding.

Authors: W Kevin Meisner; Tobin R Sosnick
Journal: Proc Natl Acad Sci U S A Date: 2004-10-25 Impact factor: 11.205

60 in total

1. A "Link-Psi" strategy using crosslinking indicates that the folding transition state of ubiquitin is not very malleable.

Authors: Ali T Shandiz; Michael C Baxa; Tobin R Sosnick
Journal: Protein Sci Date: 2012-04-23 Impact factor: 6.725

The folding of single domain proteins--have we reached a consensus?

1. Transition state heterogeneity in GCN4 coiled coil folding studied by using multisite mutations and crosslinking.

2. A simple model for calculating the kinetics of protein folding from three-dimensional structures.

3. Differences in the folding transition state of ubiquitin indicated by phi and psi analyses.

4. Structural examination of phi-value analysis in protein folding.

5. Protein folding: the stepwise assembly of foldon units.

6. Specific collapse followed by slow hydrogen-bond formation of beta-sheet in the folding of single-chain monellin.

7. Scanning malleable transition state ensembles: comparing theory and experiment for folding protein U1A.

8. Ubiquitin folds through a highly polarized transition state.

9. Desolvation is a likely origin of robust enthalpic barriers to protein folding.

10. Barrier-limited, microsecond folding of a stable protein measured with hydrogen exchange: Implications for downhill folding.

1. A "Link-Psi" strategy using crosslinking indicates that the folding transition state of ubiquitin is not very malleable.

2. Design, synthesis, and photochemical validation of peptide linchpins containing the S,S-tetrazine phototrigger.

3. Fold and flexibility: what can proteins' mechanical properties tell us about their folding nucleus?

4. Force-dependent switch in protein unfolding pathways and transition-state movements.

5. Revealing what gets buried first in protein folding.

6. A quantitative measure for protein conformational heterogeneity.

7. Probing the protein-folding mechanism using denaturant and temperature effects on rate constants.

8. Folding of a large protein at high structural resolution.

Review 9. The Mechanism and Function of Group II Chaperonins.

10. Viewing folding of nascent polypeptide chains from ribosomes.