| Literature DB >> 21137109 |
Robert A Gatenby1, Robert J Gillies, Joel S Brown.
Abstract
Multicellular organisms must evolve mechanisms to suppress cancer formation prior to reproduction, and we propose that the organizational structure of normal epithelium is one such strategy. Understanding evolved host cancer suppression mechanisms is essential to defining the first steps of carcinogenesis and developing rational cancer prevention strategies.Entities:
Mesh:
Year: 2010 PMID: 21137109 PMCID: PMC3744108 DOI: 10.1038/nrc2892
Source DB: PubMed Journal: Nat Rev Cancer ISSN: 1474-175X Impact factor: 60.716