| Literature DB >> 21135918 |
John T Gupton1, Nakul Telang, Edith J Banner, Emily J Kluball, Kayleigh E Hall, Kara L Finzel, Xin Jia, Spencer R Bates, R Scott Welden, Benjamin C Giglio, James E Eaton, Peter J Barelli, Lauren T Firich, John A Stafford, Matthew B Coppock, Eric F Worrall, Rene P F Kanters, Kerry Keertikar, Rebecca Osterman.
Abstract
Studies directed at the synthesis of (Z)-5-benzylidene-4-arylpyrrol-2(5H)-ones from (Z)-3-aryl-3-haloenoic acids are described. The successful strategy relies on the preparation of (Z)-3-aryl-3-haloenoic acids from acetophenones through the corresponding (Z)-3-aryl-3-haloenals and the conversion of the (Z)-3-aryl-3-haloenoic acids to (Z)-5-benzylidene-4-aryl-5H-furan-2-ones. The furanones were subsequently treated with primary amines and dehydrated to the corresponding (Z)-5-benzylidene-4-arylpyrrol-2(5H)-ones.Entities:
Year: 2010 PMID： 21135918 PMCID： PMC2997076 DOI： 10.1016/j.tet.2010.09.080
Source DB: PubMed Journal: Tetrahedron ISSN： 0040-4020 Impact factor: 2.457