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Literature DB >> 12729663

Multidrug resistance reversal activity of key ningalin analogues.

Danielle R Soenen¹, Inkyu Hwang, Michael P Hedrick, Dale L Boger.

Abstract

Key analogue derivatives of the ningalins, potent multidrug resistance (MDR) reversal compounds, were examined resulting in the discovery of a potent MDR reversal agent that hypersensitizes P-gp resistant tumor cell lines to front-line conventional therapeutic agents.

Entities: Chemical Disease Gene

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Year: 2003 PMID： 12729663 DOI： 10.1016/s0960-894x(03)00294-4

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

9 in total

1. Total synthesis of ningalin D.

Authors: Akiyuki Hamasaki; Jeffrey M Zimpleman; Inkyu Hwang; Dale L Boger
Journal: J Am Chem Soc Date: 2005-08-03 Impact factor: 15.419

2. The application of (Z)-3-aryl-3-haloenoic acids to the synthesis of (Z)-5-benzylidene-4-arylpyrrol-2(5H)-ones.

Authors: John T Gupton; Nakul Telang; Edith J Banner; Emily J Kluball; Kayleigh E Hall; Kara L Finzel; Xin Jia; Spencer R Bates; R Scott Welden; Benjamin C Giglio; James E Eaton; Peter J Barelli; Lauren T Firich; John A Stafford; Matthew B Coppock; Eric F Worrall; Rene P F Kanters; Kerry Keertikar; Rebecca Osterman
Journal: Tetrahedron Date: 2010-11-20 Impact factor: 2.457

Review 3. Inverse Electron Demand Diels-Alder Reactions of Heterocyclic Azadienes, 1-Aza-1,3-Butadienes, Cyclopropenone Ketals, and Related Systems. A Retrospective.

Authors: Jiajun Zhang; Vyom Shukla; Dale L Boger
Journal: J Org Chem Date: 2019-05-23 Impact factor: 4.354

Review 4. A decennary update on applications of metal nanoparticles (MNPs) in the synthesis of nitrogen- and oxygen-containing heterocyclic scaffolds.

Authors: Tejas M Dhameliya; Hiren A Donga; Punit V Vaghela; Bhoomi G Panchal; Dipen K Sureja; Kunjan B Bodiwala; Mahesh T Chhabria
Journal: RSC Adv Date: 2020-09-03 Impact factor: 4.036

Multidrug resistance reversal activity of key ningalin analogues.

1. Total synthesis of ningalin D.

2. The application of (Z)-3-aryl-3-haloenoic acids to the synthesis of (Z)-5-benzylidene-4-arylpyrrol-2(5H)-ones.

Review 3. Inverse Electron Demand Diels-Alder Reactions of Heterocyclic Azadienes, 1-Aza-1,3-Butadienes, Cyclopropenone Ketals, and Related Systems. A Retrospective.

Review 4. A decennary update on applications of metal nanoparticles (MNPs) in the synthesis of nitrogen- and oxygen-containing heterocyclic scaffolds.

Review 5. Lamellarins and related pyrrole-derived alkaloids from marine organisms.

Review 6. Discovering natural product modulators to overcome multidrug resistance in cancer chemotherapy.

Review 7. Natural Products as Alternative Choices for P-Glycoprotein (P-gp) Inhibition.

Review 8. The Effects of Synthetically Modified Natural Compounds on ABC Transporters.

9. One-pot multi-component synthesis of novel chromeno[4,3-b]pyrrol-3-yl derivatives as alpha-glucosidase inhibitors.