Literature DB >> 21135249

And four equals one: presenilin takes the gamma-secretase role by itself.

Christian B Lessard1, Steven L Wagner, Edward H Koo.   

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Year:  2010        PMID： 21135249      PMCID： PMC3003118          DOI： 10.1073/pnas.1016284108

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


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  14 in total

Review 1.  Gamma-secretase: proteasome of the membrane?

Authors:  Raphael Kopan; Ma Xenia G Ilagan
Journal:  Nat Rev Mol Cell Biol       Date:  2004-06       Impact factor: 94.444

2.  Active gamma-secretase complexes contain only one of each component.

Authors:  Toru Sato; Thekla S Diehl; Saravanakumar Narayanan; Satoru Funamoto; Yasuo Ihara; Bart De Strooper; Harald Steiner; Christian Haass; Michael S Wolfe
Journal:  J Biol Chem       Date:  2007-10-02       Impact factor: 5.157

3.  Reconstitution of gamma-secretase activity.

Authors:  Dieter Edbauer; Edith Winkler; Joerg T Regula; Brigitte Pesold; Harald Steiner; Christian Haass
Journal:  Nat Cell Biol       Date:  2003-05       Impact factor: 28.824

4.  The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.

Authors:  J Kang; H G Lemaire; A Unterbeck; J M Salbaum; C L Masters; K H Grzeschik; G Multhaup; K Beyreuther; B Müller-Hill
Journal:  Nature       Date:  1987 Feb 19-25       Impact factor: 49.962

5.  Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.

Authors:  M S Wolfe; W Xia; B L Ostaszewski; T S Diehl; W T Kimberly; D J Selkoe
Journal:  Nature       Date:  1999-04-08       Impact factor: 49.962

6.  Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.

Authors:  B De Strooper; P Saftig; K Craessaerts; H Vanderstichele; G Guhde; W Annaert; K Von Figura; F Van Leuven
Journal:  Nature       Date:  1998-01-22       Impact factor: 49.962

7.  Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.

Authors:  G Thinakaran; D R Borchelt; M K Lee; H H Slunt; L Spitzer; G Kim; T Ratovitsky; F Davenport; C Nordstedt; M Seeger; J Hardy; A I Levey; S E Gandy; N A Jenkins; N G Copeland; D L Price; S S Sisodia
Journal:  Neuron       Date:  1996-07       Impact factor: 17.173

8.  Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.

Authors:  Y M Li; M Xu; M T Lai; Q Huang; J L Castro; J DiMuzio-Mower; T Harrison; C Lellis; A Nadin; J G Neduvelil; R B Register; M K Sardana; M S Shearman; A L Smith; X P Shi; K C Yin; J A Shafer; S J Gardell
Journal:  Nature       Date:  2000-06-08       Impact factor: 49.962

9.  PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

Authors:  Wen-jie Luo; Hong Wang; Hongqiao Li; Benny S Kim; Sanjiv Shah; Hahn-Jun Lee; Gopal Thinakaran; Tae-Wan Kim; Gang Yu; Huaxi Xu
Journal:  J Biol Chem       Date:  2003-01-08       Impact factor: 5.157

10.  Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.

Authors:  R Sherrington; E I Rogaev; Y Liang; E A Rogaeva; G Levesque; M Ikeda; H Chi; C Lin; G Li; K Holman; T Tsuda; L Mar; J F Foncin; A C Bruni; M P Montesi; S Sorbi; I Rainero; L Pinessi; L Nee; I Chumakov; D Pollen; A Brookes; P Sanseau; R J Polinsky; W Wasco; H A Da Silva; J L Haines; M A Perkicak-Vance; R E Tanzi; A D Roses; P E Fraser; J M Rommens; P H St George-Hyslop
Journal:  Nature       Date:  1995-06-29       Impact factor: 49.962
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  6 in total

Review 1.  γ-Secretase and its modulators: Twenty years and beyond.

Authors:  Weiming Xia
Journal:  Neurosci Lett       Date:  2019-02-11       Impact factor: 3.046

2.  Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.

Authors:  Christian B Lessard; Edgardo Rodriguez; Thomas B Ladd; Lisa M Minter; Barbara A Osborne; Lucio Miele; Todd E Golde; Yong Ran
Journal:  J Biol Chem       Date:  2019-06-05       Impact factor: 5.157

3.  Familial Alzheimer disease presenilin-1 mutations alter the active site conformation of γ-secretase.

Authors:  De-Ming Chau; Christina J Crump; Jennifer C Villa; David A Scheinberg; Yue-Ming Li
Journal:  J Biol Chem       Date:  2012-03-29       Impact factor: 5.157

4.  Clinical and molecular studies reveal a PSEN1 mutation (L153V) in a Peruvian family with early-onset Alzheimer's disease.

Authors:  Mario R Cornejo-Olivas; Chang-En Yu; Pilar Mazzetti; Ignacio F Mata; Maria Meza; Saul Lindo-Samanamud; James B Leverenz; Thomas D Bird
Journal:  Neurosci Lett       Date:  2014-02-02       Impact factor: 3.046

5.  γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not.

Authors:  Christian B Lessard; Edgardo Rodriguez; Thomas B Ladd; Lisa M Minter; Barbara A Osborne; Lucio Miele; Todd E Golde; Yong Ran
Journal:  Alzheimers Res Ther       Date:  2020-05-19       Impact factor: 6.982

6.  proBDNF is modified by advanced glycation end products in Alzheimer's disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing.

Authors:  Catherine Fleitas; Gerard Piñol-Ripoll; Pau Marfull; Daniel Rocandio; Isidro Ferrer; Claire Rampon; Joaquim Egea; Carme Espinet
Journal:  Mol Brain       Date:  2018-11-14       Impact factor: 4.041
  6 in total

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