| Literature DB >> 21127785 |
Hyockman Kwon1, Kiwon Lee, Hae-Jo Kim.
Abstract
A nonfluorescent coumarin-malonitrile conjugate (1) was transformed into a strongly fluorescent molecule through the Michael addition of a thiol group to the α,β-unsaturated malonitrile of 1. The molecular probe has exhibited a highly selective fluorescence response toward biothiols (Cys, Hcy, GSH) with micromolar sensitivity both in vitro and in vivo.Entities:
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Year: 2010 PMID： 21127785 DOI： 10.1039/c0cc04092d
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222