Immobilization of amphiphilic dendron on silica particles toward the application to ultrahigh pressure liquid chromatography.

Amphiphilic poly(amido amine) (PAMAM) dendrons were immobilized on the surface of silica particles, following the solid phase strategy. PAMAM dendrons were constructed by the repetitive feeding of methyl acrylate and ethylenediamine as the monomers. The peripheral functionalization of amine to long alkyl ends generated the amphiphilic PAMAM dendron on the silica surface. These amphiphilic dendron-modified silica particles were applicable as new packing materials for ultrahigh pressure liquid chromatography.