OBJECTIVE: The present trial is aimed to evaluate the effectiveness of early transtympanic steroid injection in patients with 'poor prognosis' idiopathic sensorineural sudden hearing loss (ISSHL). METHODS:Seventy-six patients, diagnosed as having ISSHL with 'poor prognosis', were randomized into a transtympanic group and a control group. Thirty-nine patients receivedconventional steroid treatment and 37 patients received 4 courses of additional transtympanic injections of methylprednisolone 7 days after conventional steroid treatment. RESULTS: In the transtympanic group 45.9% of the patients had at least 15 dB improvement in pure tone average compared with 20.5% of the patients in the control group at the 8-week follow-up audiogram. In the transtympanic group 43.2% of the patients had an improvement of ≥ 15% in speech discrimination, compared with 17.9% of the patients in the control group 8 weeks after the treatment. The differences between the 2 groups were statistically significantly. CONCLUSION: The outcome was better for the patients with 'poor prognosis' ISSHL if the transtympanic steroid therapy could be applied early.
RCT Entities:
OBJECTIVE: The present trial is aimed to evaluate the effectiveness of early transtympanic steroid injection in patients with 'poor prognosis' idiopathic sensorineural sudden hearing loss (ISSHL). METHODS: Seventy-six patients, diagnosed as having ISSHL with 'poor prognosis', were randomized into a transtympanic group and a control group. Thirty-nine patients received conventional steroid treatment and 37 patients received 4 courses of additional transtympanic injections of methylprednisolone 7 days after conventional steroid treatment. RESULTS: In the transtympanic group 45.9% of the patients had at least 15 dB improvement in pure tone average compared with 20.5% of the patients in the control group at the 8-week follow-up audiogram. In the transtympanic group 43.2% of the patients had an improvement of ≥ 15% in speech discrimination, compared with 17.9% of the patients in the control group 8 weeks after the treatment. The differences between the 2 groups were statistically significantly. CONCLUSION: The outcome was better for the patients with 'poor prognosis' ISSHL if the transtympanic steroid therapy could be applied early.
Authors: Petros V Vlastarakos; George Papacharalampous; Paul Maragoudakis; George Kampessis; Nicholas Maroudias; Dimitrios Candiloros; Thomas P Nikolopoulos Journal: Eur Arch Otorhinolaryngol Date: 2011-08-19 Impact factor: 2.503
Authors: Stefan K Plontke; Christoph Meisner; Sumit Agrawal; Per Cayé-Thomasen; Kevin Galbraith; Anthony A Mikulec; Lorne Parnes; Yaamini Premakumar; Julia Reiber; Anne Gm Schilder; Arne Liebau Journal: Cochrane Database Syst Rev Date: 2022-07-22
Authors: Jia Hui Ng; Roger Chun Man Ho; Crystal Shuk Jin Cheong; Adele Ng; Heng Wai Yuen; Raymond Yeow Seng Ngo Journal: Eur Arch Otorhinolaryngol Date: 2014-09-13 Impact factor: 2.503