| Literature DB >> 21122812 |
Adam Stewart1, Nadine Wu, Jonathan Cachat, Peter Hart, Siddharth Gaikwad, Keith Wong, Eli Utterback, Thomas Gilder, Evan Kyzar, Alan Newman, Dillon Carlos, Katie Chang, Molly Hook, Catherine Rhymes, Michael Caffery, Mitchell Greenberg, James Zadina, Allan V Kalueff.
Abstract
Zebrafish (Danio rerio) are becoming increasingly popular in neurobehavioral research. Here, we summarize recent data on behavioral responses of adult zebrafish to a wide spectrum of putative anxiolytic and anxiogenic agents. Using the novel tank test as a sensitive and efficient behavioral assay, zebrafish anxiety-like behavior can be bi-directionally modulated by drugs affecting the gamma-aminobutyric acid, monoaminergic, cholinergic, glutamatergic and opioidergic systems. Complementing human and rodent data, zebrafish drug-evoked phenotypes obtained in this test support this species as a useful model for neurobehavioral and psychopharmacological research.Entities:
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Year: 2010 PMID： 21122812 DOI： 10.1016/j.pnpbp.2010.11.035
Source DB: PubMed Journal: Prog Neuropsychopharmacol Biol Psychiatry ISSN： 0278-5846 Impact factor: 5.067