BACKGROUND: Obstructive sleep apnea syndrome (OSAS) may promote hyperglycemia and insulin resistance. OBJECTIVE: We studied the link between sleep apnea and microvascular diabetic complications in veterans with type 2 diabetes mellitus (DM-2). DESIGN: A retrospective electronic chart of all veterans referred for sleep studies over a 1-year period was reviewed. Ninety-eight patients with a glycosylated hemoglobin < 6.5% were included in the study. The degree of glycemia (HbA1c) and presence of macro- and microvascular complications were compared with OSAS variables. METHOD: Statistical analysis examined bivariate associations between OSAS variables and metabolic syndrome parameters. RESULTS: The apnea hypopnea index was significantly related to diabetic microvascular complications, particularly retinopathy. Oxygen desaturation was significantly and inversely related to microalbuminuria, microvascular complications, retinopathy, and HbA1c. CONCLUSIONS: Sleep apnea is associated with microvascular complications even in well-controlled DM-2 veterans. CLINICAL IMPLICATIONS: Screening for OSAS should be considered in patients with DM-2.
BACKGROUND:Obstructive sleep apnea syndrome (OSAS) may promote hyperglycemia and insulin resistance. OBJECTIVE: We studied the link between sleep apnea and microvascular diabetic complications in veterans with type 2 diabetes mellitus (DM-2). DESIGN: A retrospective electronic chart of all veterans referred for sleep studies over a 1-year period was reviewed. Ninety-eight patients with a glycosylated hemoglobin < 6.5% were included in the study. The degree of glycemia (HbA1c) and presence of macro- and microvascular complications were compared with OSAS variables. METHOD: Statistical analysis examined bivariate associations between OSAS variables and metabolic syndrome parameters. RESULTS: The apnea hypopnea index was significantly related to diabetic microvascular complications, particularly retinopathy. Oxygen desaturation was significantly and inversely related to microalbuminuria, microvascular complications, retinopathy, and HbA1c. CONCLUSIONS:Sleep apnea is associated with microvascular complications even in well-controlled DM-2 veterans. CLINICAL IMPLICATIONS: Screening for OSAS should be considered in patients with DM-2.
Authors: Hind El Ouardighi; Kris G Poppe; Pierre Kleynen; Lidia Grabzcan; Flora Veltri; Anne Violette Bruyneel; Pham Anh Hong Nguyen; Marie Bruyneel Journal: Sleep Breath Date: 2022-02-09 Impact factor: 2.816
Authors: M Fusetti; A B Fioretti; M Valenti; F Masedu; M Lauriello; M Pagliarella Journal: Acta Otorhinolaryngol Ital Date: 2012-10 Impact factor: 2.124