BACKGROUND: Primary herpes simplex virus (HSV) infection usually involves one mucosal region. OBJECTIVE: To describe an unusual disseminated HSV-1 infection involving two mucosal sites in a healthy man. RESULTS: Primary HSV infection involved oral and genital mucosa and was associated with viremia, hepatitis and rash. Phylogenetic analysis of genital and oral viruses revealed that the patient was infected by a single HSV-1 strain. CONCLUSION: Use of polymerase chain reaction detection techniques for HSV may identify viremic patients in the absence of obvious immunosuppression.
BACKGROUND: Primary herpes simplex virus (HSV) infection usually involves one mucosal region. OBJECTIVE: To describe an unusual disseminated HSV-1 infection involving two mucosal sites in a healthy man. RESULTS:Primary HSV infection involved oral and genital mucosa and was associated with viremia, hepatitis and rash. Phylogenetic analysis of genital and oral viruses revealed that the patient was infected by a single HSV-1 strain. CONCLUSION: Use of polymerase chain reaction detection techniques for HSV may identify viremic patients in the absence of obvious immunosuppression.
Authors: L R Stanberry; S A Floyd-Reising; B L Connelly; S J Alter; M J Gilchrist; C Rubio; M G Myers Journal: Clin Infect Dis Date: 1994-03 Impact factor: 9.079