Literature DB >> 21119699

How does PKMζ maintain long-term memory?

Todd C Sacktor1.   

Abstract

Most of the molecular mechanisms contributing to long-term memory have been found to consolidate information within a brief time window after learning, but not to maintain information during memory storage. However, with the discovery that synaptic long-term potentiation is maintained by the persistently active protein kinase, protein kinase Mζ (PKMζ), a possible mechanism of memory storage has been identified. Recent research shows how PKMζ might perpetuate information both at synapses and during long-term memory.

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Year:  2010        PMID: 21119699     DOI: 10.1038/nrn2949

Source DB:  PubMed          Journal:  Nat Rev Neurosci        ISSN: 1471-003X            Impact factor:   34.870


  59 in total

1.  PKMzeta maintains memories by regulating GluR2-dependent AMPA receptor trafficking.

Authors:  Paola Virginia Migues; Oliver Hardt; Dong Chuan Wu; Karine Gamache; Todd Charlton Sacktor; Yu Tian Wang; Karim Nader
Journal:  Nat Neurosci       Date:  2010-04-11       Impact factor: 24.884

2.  Involvement of the CA3-CA1 synapse in the acquisition of associative learning in behaving mice.

Authors:  Agnès Gruart; María Dolores Muñoz; José M Delgado-García
Journal:  J Neurosci       Date:  2006-01-25       Impact factor: 6.167

3.  A quantitative model for the kinetics of cAMP-dependent protein kinase (type II) activity. Long-term activation of the kinase and its possible relevance to learning and memory.

Authors:  J D Buxbaum; Y Dudai
Journal:  J Biol Chem       Date:  1989-06-05       Impact factor: 5.157

4.  AMPA receptor signaling through BRAG2 and Arf6 critical for long-term synaptic depression.

Authors:  Ralf Scholz; Sven Berberich; Louisa Rathgeber; Alexander Kolleker; Georg Köhr; Hans-Christian Kornau
Journal:  Neuron       Date:  2010-06-10       Impact factor: 17.173

5.  Molecular biology of learning: modulation of transmitter release.

Authors:  E R Kandel; J H Schwartz
Journal:  Science       Date:  1982-10-29       Impact factor: 47.728

6.  Hippocampal-dependent spatial memory functions might be lateralized in rats: An approach combining gene expression profiling and reversible inactivation.

Authors:  Sandra Klur; Christophe Muller; Anne Pereira de Vasconcelos; Theresa Ballard; Joëlle Lopez; Rodrigue Galani; Ulrich Certa; Jean-Christophe Cassel
Journal:  Hippocampus       Date:  2009-09       Impact factor: 3.899

7.  Erasing sensorimotor memories via PKMzeta inhibition.

Authors:  Lee Michael von Kraus; Todd Charlton Sacktor; Joseph Thachil Francis
Journal:  PLoS One       Date:  2010-06-15       Impact factor: 3.240

8.  A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia.

Authors:  Kausik Si; Maurizio Giustetto; Amit Etkin; Ruby Hsu; Agnieszka M Janisiewicz; Maria Conchetta Miniaci; Joung-Hun Kim; Huixiang Zhu; Eric R Kandel
Journal:  Cell       Date:  2003-12-26       Impact factor: 41.582

9.  Schemas and memory consolidation.

Authors:  Dorothy Tse; Rosamund F Langston; Masaki Kakeyama; Ingrid Bethus; Patrick A Spooner; Emma R Wood; Menno P Witter; Richard G M Morris
Journal:  Science       Date:  2007-04-06       Impact factor: 47.728

10.  NSF binding to GluR2 regulates synaptic transmission.

Authors:  A Nishimune; J T Isaac; E Molnar; J Noel; S R Nash; M Tagaya; G L Collingridge; S Nakanishi; J M Henley
Journal:  Neuron       Date:  1998-07       Impact factor: 17.173

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  157 in total

Review 1.  The Biology of Forgetting-A Perspective.

Authors:  Ronald L Davis; Yi Zhong
Journal:  Neuron       Date:  2017-08-02       Impact factor: 17.173

Review 2.  NMDA receptors and metaplasticity: mechanisms and possible roles in neuropsychiatric disorders.

Authors:  Charles F Zorumski; Yukitoshi Izumi
Journal:  Neurosci Biobehav Rev       Date:  2012-01-02       Impact factor: 8.989

3.  Overexpression of PKMζ alters morphology and function of dendritic spines in cultured cortical neurons.

Authors:  Shiri Ron; Yadin Dudai; Menahem Segal
Journal:  Cereb Cortex       Date:  2011-11-28       Impact factor: 5.357

Review 4.  Mapping molecular memory: navigating the cellular pathways of learning.

Authors:  Gavin R Owen; Elisabeth Anne Brenner
Journal:  Cell Mol Neurobiol       Date:  2012-04-10       Impact factor: 5.046

5.  Synaptic distributions of GluA2 and PKMζ in the monkey dentate gyrus and their relationships with aging and memory.

Authors:  Yuko Hara; Michael Punsoni; Frank Yuk; C Sehwan Park; William G M Janssen; Peter R Rapp; John H Morrison
Journal:  J Neurosci       Date:  2012-05-23       Impact factor: 6.167

Review 6.  Structural plasticity upon learning: regulation and functions.

Authors:  Pico Caroni; Flavio Donato; Dominique Muller
Journal:  Nat Rev Neurosci       Date:  2012-06-20       Impact factor: 34.870

Review 7.  The Role of Proteases in Hippocampal Synaptic Plasticity: Putting Together Small Pieces of a Complex Puzzle.

Authors:  Ivan L Salazar; Margarida V Caldeira; Michele Curcio; Carlos B Duarte
Journal:  Neurochem Res       Date:  2015-11-07       Impact factor: 3.996

Review 8.  Finding the engram.

Authors:  Sheena A Josselyn; Stefan Köhler; Paul W Frankland
Journal:  Nat Rev Neurosci       Date:  2015-09       Impact factor: 34.870

Review 9.  Molecular Mechanisms of the Memory Trace.

Authors:  Arun Asok; Félix Leroy; Joseph B Rayman; Eric R Kandel
Journal:  Trends Neurosci       Date:  2018-10-31       Impact factor: 13.837

10.  Inhibition of protein kinase Mζ disrupts the stable spatial discharge of hippocampal place cells in a familiar environment.

Authors:  Jeremy M Barry; Bruno Rivard; Steven E Fox; Andre A Fenton; Todd C Sacktor; Robert U Muller
Journal:  J Neurosci       Date:  2012-10-03       Impact factor: 6.167

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