BACKGROUND: Previous diffusion tensor imaging (DTI) studies in patients with obsessive-compulsive disorder (OCD) have reported inconsistent findings, and it is not known whether observed findings are related to abnormalities in axonal structure or myelination. METHODS: In this DTI study, we investigated fractional anisotropy, as well as axial and radial diffusivity, in 21 patients with OCD and 29 healthy controls. RESULTS: We found decreased fractional anisotropy in the body of the corpus callosum in the OCD group, which was underpinned by increased radial diffusivity. LIMITATIONS: The cross-sectional design was the main limitation. CONCLUSION: Our findings of increased radial diffusivity provide preliminary evidence for abnormal myelination in patients with OCD.
BACKGROUND: Previous diffusion tensor imaging (DTI) studies in patients with obsessive-compulsive disorder (OCD) have reported inconsistent findings, and it is not known whether observed findings are related to abnormalities in axonal structure or myelination. METHODS: In this DTI study, we investigated fractional anisotropy, as well as axial and radial diffusivity, in 21 patients with OCD and 29 healthy controls. RESULTS: We found decreased fractional anisotropy in the body of the corpus callosum in the OCD group, which was underpinned by increased radial diffusivity. LIMITATIONS: The cross-sectional design was the main limitation. CONCLUSION: Our findings of increased radial diffusivity provide preliminary evidence for abnormal myelination in patients with OCD.
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