BACKGROUND: Moderate alcohol consumption may have certain beneficial effects against non-alcoholic fatty liver disease, which is associated with metabolic syndrome. AIM: To determine the association between drinking pattern and fatty liver in Japanese men and women. METHODS: A cross-sectional study was performed with health checkup data including information concerning alcohol consumption and ultrasonographic assessment of fatty liver. RESULTS: We analysed 4957 men and 2155 women without reported liver diseases (median age, 49 years). In men, 40% of nondrinkers and 28% of drinkers had fatty liver. Alcohol consumption was inversely associated with fatty liver (adjusted odds ratio, 0.54; 95% confidence interval, 0.46-0.63). The prevalence of fatty liver in each category of drinking frequency was 38% (1-3 days/week), 29% (4-6 days/week), and 24% (daily drinking); there was a significant inverse correlation between drinking frequency and the prevalence of fatty liver (P < 0.001). In women, 16% of nondrinkers and 10% of drinkers had fatty liver. Drinking less than 20 g on 1-3 days/week was associated with low prevalence of fatty liver (adjusted odds ratio, 0.47; 95% confidence interval, 0.23-0.96). CONCLUSIONS: Alcohol consumption appears to protect against non-alcoholic fatty liver disease.
BACKGROUND: Moderate alcohol consumption may have certain beneficial effects against non-alcoholic fatty liver disease, which is associated with metabolic syndrome. AIM: To determine the association between drinking pattern and fatty liver in Japanese men and women. METHODS: A cross-sectional study was performed with health checkup data including information concerning alcohol consumption and ultrasonographic assessment of fatty liver. RESULTS: We analysed 4957 men and 2155 women without reported liver diseases (median age, 49 years). In men, 40% of nondrinkers and 28% of drinkers had fatty liver. Alcohol consumption was inversely associated with fatty liver (adjusted odds ratio, 0.54; 95% confidence interval, 0.46-0.63). The prevalence of fatty liver in each category of drinking frequency was 38% (1-3 days/week), 29% (4-6 days/week), and 24% (daily drinking); there was a significant inverse correlation between drinking frequency and the prevalence of fatty liver (P < 0.001). In women, 16% of nondrinkers and 10% of drinkers had fatty liver. Drinking less than 20 g on 1-3 days/week was associated with low prevalence of fatty liver (adjusted odds ratio, 0.47; 95% confidence interval, 0.23-0.96). CONCLUSIONS:Alcohol consumption appears to protect against non-alcoholic fatty liver disease.
Authors: Sylvia H Ley; Qi Sun; Monik C Jimenez; Kathryn M Rexrode; Joann E Manson; Majken K Jensen; Eric B Rimm; Frank B Hu Journal: Diabetologia Date: 2013-10-09 Impact factor: 10.122
Authors: Bo Wang; Zhixiu Wang; Jeanene M de Avila; Mei-Jun Zhu; Faya Zhang; Noe Alberto Gomez; Liang Zhao; Qiyu Tian; Junxing Zhao; Joseph Maricelli; Hui Zhang; Buel D Rodgers; Min Du Journal: FASEB J Date: 2017-07-05 Impact factor: 5.191