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Literature DB >> 21115811

Rapamycin induces autophagic flux in neurons.

David C Rubinsztein, Ralph A Nixon.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 2010 PMID： 21115811 PMCID： PMC3000262 DOI： 10.1073/pnas.1014633107

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

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5 in total

1. Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease.

Authors: Barry Boland; Asok Kumar; Sooyeon Lee; Frances M Platt; Jerzy Wegiel; W Haung Yu; Ralph A Nixon
Journal: J Neurosci Date: 2008-07-02 Impact factor: 6.167

2. A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model.

Authors: Andrey S Tsvetkov; Jason Miller; Montserrat Arrasate; Jinny S Wong; Michael A Pleiss; Steven Finkbeiner
Journal: Proc Natl Acad Sci U S A Date: 2010-09-10 Impact factor: 11.205

3. Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy.

Authors: Leslie Crews; Brian Spencer; Paula Desplats; Christina Patrick; Amy Paulino; Edward Rockenstein; Lawrence Hansen; Anthony Adame; Douglas Galasko; Eliezer Masliah
Journal: PLoS One Date: 2010-02-19 Impact factor: 3.240

4. The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease.

Authors: Jonathan H Fox; Teal Connor; Vanita Chopra; Kate Dorsey; Jibrin A Kama; Dorothee Bleckmann; Claudia Betschart; Daniel Hoyer; Stefan Frentzel; Marian Difiglia; Paolo Paganetti; Steven M Hersch
Journal: Mol Neurodegener Date: 2010-06-22 Impact factor: 14.195

5. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease.

Authors: Claudia Rose; Fiona M Menzies; Maurizio Renna; Abraham Acevedo-Arozena; Silvia Corrochano; Oana Sadiq; Steve D Brown; David C Rubinsztein
Journal: Hum Mol Genet Date: 2010-02-27 Impact factor: 6.150

5 in total

12 in total

Review 1. Lysosome trafficking and signaling in health and neurodegenerative diseases.

Authors: Pearl P Y Lie; Ralph A Nixon
Journal: Neurobiol Dis Date: 2018-05-30 Impact factor: 5.996

Review 2. Changes in the osteocyte lacunocanalicular network with aging.

Authors: LeAnn M Tiede-Lewis; Sarah L Dallas
Journal: Bone Date: 2019-02-08 Impact factor: 4.398

3. ATP13A2 regulates mitochondrial bioenergetics through macroautophagy.

Authors: Aaron M Gusdon; Jianhui Zhu; Bennett Van Houten; Charleen T Chu
Journal: Neurobiol Dis Date: 2011-12-13 Impact factor: 5.996

Review 4. Autophagy failure in Alzheimer's disease--locating the primary defect.

Authors: Ralph A Nixon; Dun-Sheng Yang
Journal: Neurobiol Dis Date: 2011-02-03 Impact factor: 5.996

Review 5. Modulating macroautophagy: a neuronal perspective.

Authors: Christopher W Johnson; Thomas J Melia; Ai Yamamoto
Journal: Future Med Chem Date: 2012-09 Impact factor: 3.808

6. AMPK activation does not enhance autophagy in neurons in contrast to MTORC1 inhibition: different impact on β-amyloid clearance.

Authors: Irene Benito-Cuesta; Lara Ordóñez-Gutiérrez; Francisco Wandosell
Journal: Autophagy Date: 2020-02-20 Impact factor: 16.016

7. Single-walled carbon nanotubes alleviate autophagic/lysosomal defects in primary glia from a mouse model of Alzheimer's disease.

Authors: Xue Xue; Li-Rong Wang; Yutaka Sato; Ying Jiang; Martin Berg; Dun-Sheng Yang; Ralph A Nixon; Xing-Jie Liang
Journal: Nano Lett Date: 2014-08-21 Impact factor: 11.189