Literature DB >> 21114567

The role of the foreskin in male circumcision: an evidence-based review.

Minh H Dinh1, Kelly M Fahrbach, Thomas J Hope.   

Abstract

HIV sexual transmission via the male genital tract remains poorly defined. Male circumcision was shown to reduce female-to-male transmission in Africa, providing a clue that the foreskin plays a role in the route of transmission. Scientific data in four categories relating to how the foreskin might affect HIV transmission is summarized: (i) surface area, (ii) microbiologic environment, (iii) HIV-1-susceptible cells, and (iv) tissue structure. The relative contribution of each of these areas is yet unknown, and further studies will be crucial in understanding how male circumcision affects HIV transmission in men.
© 2010 John Wiley & Sons A/S.

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Year:  2010        PMID： 21114567      PMCID： PMC3091617          DOI： 10.1111/j.1600-0897.2010.00934.x

Source DB:  PubMed          Journal:  Am J Reprod Immunol        ISSN： 1046-7408            Impact factor:   3.886


  25 in total

1.  Sealing the live part of the skin: the integrated meshwork of desmosomes, tight junctions and curvilinear ridge structures in the cells of the uppermost granular layer of the human epidermis.

Authors:  Holger Schlüter; Roger Wepf; Ingrid Moll; Werner W Franke
Journal:  Eur J Cell Biol       Date:  2004-12       Impact factor: 4.492

2.  Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial.

Authors:  Ronald H Gray; Godfrey Kigozi; David Serwadda; Frederick Makumbi; Stephen Watya; Fred Nalugoda; Noah Kiwanuka; Lawrence H Moulton; Mohammad A Chaudhary; Michael Z Chen; Nelson K Sewankambo; Fred Wabwire-Mangen; Melanie C Bacon; Carolyn F M Williams; Pius Opendi; Steven J Reynolds; Oliver Laeyendecker; Thomas C Quinn; Maria J Wawer
Journal:  Lancet       Date:  2007-02-24       Impact factor: 79.321

3.  Enhanced cellular responses and environmental sampling within inner foreskin explants: implications for the foreskin's role in HIV transmission.

Authors:  K M Fahrbach; S M Barry; M R Anderson; T J Hope
Journal:  Mucosal Immunol       Date:  2010-04-21       Impact factor: 7.313

4.  Potential HIV-1 target cells in the human penis.

Authors:  Scott G McCoombe; Roger V Short
Journal:  AIDS       Date:  2006-07-13       Impact factor: 4.177

5.  Comparative investigation of Langerhans' cells and potential receptors for HIV in oral, genitourinary and rectal epithelia.

Authors:  L A Hussain; T Lehner
Journal:  Immunology       Date:  1995-07       Impact factor: 7.397

6.  Comparison of female to male and male to female transmission of HIV in 563 stable couples. European Study Group on Heterosexual Transmission of HIV.

Authors: 
Journal:  BMJ       Date:  1992-03-28

7.  Intrinsic aging vs. photoaging: a comparative histopathological, immunohistochemical, and ultrastructural study of skin.

Authors:  M El-Domyati; S Attia; F Saleh; D Brown; D E Birk; F Gasparro; H Ahmad; J Uitto
Journal:  Exp Dermatol       Date:  2002-10       Impact factor: 3.960

8.  Susceptibility to human immunodeficiency virus-1 infection of human foreskin and cervical tissue grown in explant culture.

Authors:  Bruce K Patterson; Alan Landay; Joan N Siegel; Zareefa Flener; Dennis Pessis; Antonio Chaviano; Robert C Bailey
Journal:  Am J Pathol       Date:  2002-09       Impact factor: 4.307

9.  Association between HIV and subpreputial penile wetness in uncircumcised men in South Africa.

Authors:  Nigel O'Farrell; Linda Morison; Prashini Moodley; Keshree Pillay; Trusha Vanmali; Maria Quigley; Richard Hayes; A Willem Sturm
Journal:  J Acquir Immune Defic Syndr       Date:  2006-09       Impact factor: 3.731

10.  Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial.

Authors:  Bertran Auvert; Dirk Taljaard; Emmanuel Lagarde; Joëlle Sobngwi-Tambekou; Rémi Sitta; Adrian Puren
Journal:  PLoS Med       Date:  2005-10-25       Impact factor: 11.069
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  12 in total

Review 1.  Voluntary medical male circumcision: an HIV prevention priority for PEPFAR.

Authors:  Jason Bailey Reed; Emmanuel Njeuhmeli; Anne Goldzier Thomas; Melanie C Bacon; Robert Bailey; Peter Cherutich; Kelly Curran; Kim Dickson; Tim Farley; Catherine Hankins; Karin Hatzold; Jessica Justman; Zebedee Mwandi; Luke Nkinsi; Renee Ridzon; Caroline Ryan; Naomi Bock
Journal:  J Acquir Immune Defic Syndr       Date:  2012-08-15       Impact factor: 3.731

Review 2.  HIV transmission.

Authors:  George M Shaw; Eric Hunter
Journal:  Cold Spring Harb Perspect Med       Date:  2012-11-01       Impact factor: 6.915

3.  Adenovirus serotype 26 and 35 vectors induce simian immunodeficiency virus-specific T lymphocyte responses in foreskin in rhesus monkeys.

Authors:  Emmanuel Balandya; Andrew D Miller; Matthew Beck; Jinyan Liu; Hualin Li; Erica Borducchi; Kaitlin Smith; Crystal Cabral; Kelly Stanley; Lori F Maxfield; Dan H Barouch
Journal:  J Virol       Date:  2014-01-15       Impact factor: 5.103

4.  Circumcision to prevent HIV and other sexually transmitted infections in men who have sex with men: a systematic review and meta-analysis of global data.

Authors:  Tanwei Yuan; Thomas Fitzpatrick; Nai-Ying Ko; Yong Cai; Yingqing Chen; Jin Zhao; Linghua Li; Junjie Xu; Jing Gu; Jinghua Li; Chun Hao; Zhengrong Yang; Weiping Cai; Chien-Yu Cheng; Zhenzhou Luo; Kechun Zhang; Guohui Wu; Xiaojun Meng; Andrew E Grulich; Yuantao Hao; Huachun Zou
Journal:  Lancet Glob Health       Date:  2019-04       Impact factor: 26.763

5.  Mass safe male circumcision: early lessons from a Ugandan urban site - a case study.

Authors:  Moses Galukande; Denis Bbaale Sekavuga; Kevin Duffy; Nicholas Wooding; Sam Rackara; Florence Nakaggwa; Teddy Nagaddya; Alex Emmanuel Elobu; Alex Coutinho
Journal:  Pan Afr Med J       Date:  2012-12-28

Review 6.  Male circumcision for HIV prevention: current evidence and implementation in sub-Saharan Africa.

Authors:  Richard G Wamai; Brian J Morris; Stefan A Bailis; David Sokal; Jeffrey D Klausner; Ross Appleton; Nelson Sewankambo; David A Cooper; John Bongaarts; Guy de Bruyn; Alex D Wodak; Joya Banerjee
Journal:  J Int AIDS Soc       Date:  2011-10-20       Impact factor: 5.396

7.  Foreskin T-cell subsets differ substantially from blood with respect to HIV co-receptor expression, inflammatory profile, and memory status.

Authors:  J L Prodger; R Gray; G Kigozi; F Nalugoda; R Galiwango; T Hirbod; M Wawer; S O P Hofer; N Sewankambo; D Serwadda; R Kaul
Journal:  Mucosal Immunol       Date:  2011-11-16       Impact factor: 7.313

8.  HIV acquisition is associated with increased antimicrobial peptides and reduced HIV neutralizing IgA in the foreskin prepuce of uncircumcised men.

Authors:  Taha Hirbod; Xiangrong Kong; Godgrey Kigozi; Anthony Ndyanabo; David Serwadda; Jessica L Prodger; Aaron A Tobian; Fred Nalugoda; Maria J Wawer; Kamnoosh Shahabi; Olga L Rojas; Jennifer L Gommerman; Kristina Broliden; Rupert Kaul; Ronald H Gray
Journal:  PLoS Pathog       Date:  2014-10-02       Impact factor: 6.823

9.  Male Circumcision and HIV Transmission; What Do We Know?

Authors:  Parana H M Jayathunge; William J H McBride; David MacLaren; John Kaldor; Andrew Vallely; Stuart Turville
Journal:  Open AIDS J       Date:  2014-09-30

10.  Male circumcision significantly reduces prevalence and load of genital anaerobic bacteria.

Authors:  Cindy M Liu; Bruce A Hungate; Aaron A R Tobian; David Serwadda; Jacques Ravel; Richard Lester; Godfrey Kigozi; Maliha Aziz; Ronald M Galiwango; Fred Nalugoda; Tania L Contente-Cuomo; Maria J Wawer; Paul Keim; Ronald H Gray; Lance B Price
Journal:  mBio       Date:  2013-04-16       Impact factor: 7.867
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