OBJECTIVES: To investigate the malignancy rate in probably benign lesions with interval growth on follow-up ultrasound (US) and the cut-off values for predicting malignancy. METHODS: By retrospective reviewing 19,435 US examinations assessed as probably benign lesions, a total of 214 lesions with interval growth in 199 patients were included. The increased volume (%V),%V per month, the most increased diameter (D), and D per month were compared between malignant and benign lesions. Malignancy rates were compared between lesions with or without newly developed suspicious malignant features. RESULTS: Twenty-two (10.3%) malignancies showed significant increase in%V,%V per month, D, and D per month compared with 192 (89.7%) benign lesions (p = 0.0083, <0.0001, <0.0001, and <0.0001, respectively). Fifteen (38.5%) of 39 lesions where suspicious features developed proved malignant, whereas 7 (4%) out of 175 without were malignant (p = 0.0011). In nodules without suspicious features, 24.2% of%V per month and 1.9 mm of D per month showed high sensitivity (85.7% and 71.4%) and specificity (67.8% and 97.6%) for predicting malignancy. CONCLUSIONS: Probably benign lesions with interval growth should undergo prompt biopsy because of the 10.3% malignancy rate. In lesions where suspicious features developed, the malignancy rate increased to 38.5%.
OBJECTIVES: To investigate the malignancy rate in probably benign lesions with interval growth on follow-up ultrasound (US) and the cut-off values for predicting malignancy. METHODS: By retrospective reviewing 19,435 US examinations assessed as probably benign lesions, a total of 214 lesions with interval growth in 199 patients were included. The increased volume (%V),%V per month, the most increased diameter (D), and D per month were compared between malignant and benign lesions. Malignancy rates were compared between lesions with or without newly developed suspicious malignant features. RESULTS: Twenty-two (10.3%) malignancies showed significant increase in%V,%V per month, D, and D per month compared with 192 (89.7%) benign lesions (p = 0.0083, <0.0001, <0.0001, and <0.0001, respectively). Fifteen (38.5%) of 39 lesions where suspicious features developed proved malignant, whereas 7 (4%) out of 175 without were malignant (p = 0.0011). In nodules without suspicious features, 24.2% of%V per month and 1.9 mm of D per month showed high sensitivity (85.7% and 71.4%) and specificity (67.8% and 97.6%) for predicting malignancy. CONCLUSIONS: Probably benign lesions with interval growth should undergo prompt biopsy because of the 10.3% malignancy rate. In lesions where suspicious features developed, the malignancy rate increased to 38.5%.
Authors: Oswald Graf; Thomas H Helbich; Michael H Fuchsjaeger; Gottfried Hopf; Margarita Morgun; Claudia Graf; Reinhold Mallek; Edward A Sickles Journal: Radiology Date: 2004-10-14 Impact factor: 11.105
Authors: A J Nixon; D Neuberg; D F Hayes; R Gelman; J L Connolly; S Schnitt; A Abner; A Recht; F Vicini; J R Harris Journal: J Clin Oncol Date: 1994-05 Impact factor: 44.544
Authors: Ja Yoon Jang; Sun Mi Kim; Jin Hwan Kim; Mijung Jang; Bo La Yun; Jong Yoon Lee; Soo Hyun Lee; Bohyoung Kim Journal: Medicine (Baltimore) Date: 2017-03 Impact factor: 1.889