Literature DB >> 21113402

(+)-Discodermolide: Total Synthesis, Construction of Novel Analogues, and Biological Evaluation.

Amos B Smith1, B Scott Freeze.   

Abstract

Entities:  

Year:  2007        PMID： 21113402      PMCID： PMC2991168          DOI： 10.1016/j.tet.2007.10.039

Source DB:  PubMed          Journal:  Tetrahedron        ISSN： 0040-4020            Impact factor:   2.457


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  72 in total

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3.  A practical synthesis of (+)-discodermolide and analogues: fragment union by complex aldol reactions.

Authors:  I Paterson; G J Florence; K Gerlach; J P Scott; N Sereinig
Journal:  J Am Chem Soc       Date:  2001-10-03       Impact factor: 15.419

4.  Structure-activity relationship studies of discodermolide and its semisynthetic acetylated analogs on microtubule function and cytotoxicity.

Authors:  R A Isbrucker; S P Gunasekera; R E Longley
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5.  Design, synthesis, and biological evaluation of potent discodermolide fluorescent and photoaffinity molecular probes.

Authors:  Amos B Smith; Paul V Rucker; Ignacio Brouard; B Scott Freeze; Shujun Xia; Susan Band Horwitz
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Review 7.  Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs.

Authors:  Mark S Forman; John Q Trojanowski; Virginia M-Y Lee
Journal:  Nat Med       Date:  2004-10       Impact factor: 53.440

8.  Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol.

Authors:  E ter Haar; R J Kowalski; E Hamel; C M Lin; R E Longley; S P Gunasekera; H S Rosenkranz; B W Day
Journal:  Biochemistry       Date:  1996-01-09       Impact factor: 3.162

9.  Taxol stabilizes microtubules in mouse fibroblast cells.

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10.  Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule- stabilizing activity.

Authors:  Kylie A Hood; Lyndon M West; Berber Rouwé; Peter T Northcote; Michael V Berridge; St John Wakefield; John H Miller
Journal:  Cancer Res       Date:  2002-06-15       Impact factor: 12.701
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  23 in total

1.  Structural Refinement of the Tubulin Ligand (+)-Discodermolide to Attenuate Chemotherapy-Mediated Senescence.

Authors:  Boying Guo; Alicia Rodriguez-Gabin; Andrea E Prota; Tobias Mühlethaler; Nan Zhang; Kenny Ye; Michel O Steinmetz; Susan Band Horwitz; Amos B Smith; Hayley M McDaid
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2.  Spongipyran Synthetic Studies. Evolution of a Scalable Total Synthesis of (+)-Spongistatin 1.

Authors:  Amos B Smith; Chris Sfouggatakis; Christina A Risatti; Jeffrey B Sperry; Wenyu Zhu; Victoria A Doughty; Takashi Tomioka; Dimitar B Gotchev; Clay S Bennett; Satoshi Sakamoto; Onur Atasoylu; Shohei Shirakami; David Bauer; Makoto Takeuchi; Jyunichi Koyanagi; Yasuharu Sakamoto
Journal:  Tetrahedron       Date:  2009-09-15       Impact factor: 2.457

Review 3.  The Lithistida: important sources of compounds useful in biomedical research.

Authors:  Amy E Wright
Journal:  Curr Opin Biotechnol       Date:  2010-12       Impact factor: 9.740

Review 4.  Conformation-activity relationships of polyketide natural products.

Authors:  Erik M Larsen; Matthew R Wilson; Richard E Taylor
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5.  Natural product synthesis at the interface of chemistry and biology.

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6.  The quest for supernatural products: the impact of total synthesis in complex natural products medicinal chemistry.

Authors:  Zhi-Chen Wu; Dale L Boger
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Review 7.  Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.

Authors:  Carlo Ballatore; Kurt R Brunden; Donna M Huryn; John Q Trojanowski; Virginia M-Y Lee; Amos B Smith
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8.  Synthesis of (+)-discodermolide by catalytic stereoselective borylation reactions.

Authors:  Zhiyong Yu; Robert J Ely; James P Morken
Journal:  Angew Chem Int Ed Engl       Date:  2014-07-15       Impact factor: 15.336

9.  Distinct pose of discodermolide in taxol binding pocket drives a complementary mode of microtubule stabilization.

Authors:  Marina Khrapunovich-Baine; Vilas Menon; Pascal Verdier-Pinard; Amos B Smith; Ruth Hogue Angeletti; Andras Fiser; Susan Band Horwitz; Hui Xiao
Journal:  Biochemistry       Date:  2009-12-15       Impact factor: 3.162

10.  Iron complexation to oxygen rich marine natural products: a computational study.

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