Literature DB >> 16268537

Design, synthesis, and biological evaluation of potent discodermolide fluorescent and photoaffinity molecular probes.

Amos B Smith1, Paul V Rucker, Ignacio Brouard, B Scott Freeze, Shujun Xia, Susan Band Horwitz.   

Abstract

[structure: see text] The design, synthesis, and biological evaluation of a series of (+)-discodermolide molecular probes possessing photoaffinity and fluorescent appendages has been achieved. Stereoselective olefin cross-metathesis comprised a key tactic for construction of two of the molecular probes. Three photoaffinity probes were radiolabeled with tritium.

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Year:  2005        PMID： 16268537     DOI： 10.1021/ol0520166

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  5 in total

1.  Structural Refinement of the Tubulin Ligand (+)-Discodermolide to Attenuate Chemotherapy-Mediated Senescence.

Authors:  Boying Guo; Alicia Rodriguez-Gabin; Andrea E Prota; Tobias Mühlethaler; Nan Zhang; Kenny Ye; Michel O Steinmetz; Susan Band Horwitz; Amos B Smith; Hayley M McDaid
Journal:  Mol Pharmacol       Date:  2020-06-26       Impact factor: 4.436

2.  (+)-Discodermolide: Total Synthesis, Construction of Novel Analogues, and Biological Evaluation.

Authors:  Amos B Smith; B Scott Freeze
Journal:  Tetrahedron       Date:  2007-01-07       Impact factor: 2.457

3.  Design, synthesis and biological evaluation of a simplified fluorescently labeled discodermolide as a molecular probe to study the binding of discodermolide to tubulin.

Authors:  Jun Qi; Adam R Blanden; Susan Bane; David G I Kingston
Journal:  Bioorg Med Chem       Date:  2011-07-02       Impact factor: 3.641

4.  Design and synthesis of (+)-discodermolide-paclitaxel hybrids leading to enhanced biological activity.

Authors:  Amos B Smith; Keizo Sugasawa; Onur Atasoylu; Chia-Ping Huang Yang; Susan Band Horwitz
Journal:  J Med Chem       Date:  2011-08-26       Impact factor: 7.446

5.  Synthesis and biological evaluation of a fluorescent analog of phenytoin as a potential inhibitor of neuropathic pain and imaging agent.

Authors:  Thomas H Walls; Scott C Grindrod; Dawn Beraud; Li Zhang; Aparna R Baheti; Sivanesan Dakshanamurthy; Manoj K Patel; Milton L Brown; Linda H MacArthur
Journal:  Bioorg Med Chem       Date:  2012-07-03       Impact factor: 3.641
  5 in total

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