Literature DB >> 211125

Nonspecific effect of m7GMP on protein-RNA interactions.

N Sonenberg, A J Shatkin.   

Abstract

Cap analogs m7GMP and m7GDP inhibit binding of eukaryotic initiation factors to reovirus capped mRNA but also inhibit complex formation involving uncapped mRNA or 18 S rRNA. Furthermore, Escherichia coli DNA-dependent RNA polymerase binds 18 S rRNA and this interaction is also blocked by m7GMP. These results indicate that inhibition by cap analogs is not a stringent test for putative cap-specific binding between proteins and mRNA.

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Year:  1978        PMID： 211125

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  12 in total

1.  The 5'-7-methylguanosine cap on eukaryotic mRNAs serves both to stimulate canonical translation initiation and to block an alternative pathway.

Authors:  Sarah F Mitchell; Sarah E Walker; Mikkel A Algire; Eun-Hee Park; Alan G Hinnebusch; Jon R Lorsch
Journal:  Mol Cell       Date:  2010-09-24       Impact factor: 17.970

2.  Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F.

Authors:  F Rozen; I Edery; K Meerovitch; T E Dever; W C Merrick; N Sonenberg
Journal:  Mol Cell Biol       Date:  1990-03       Impact factor: 4.272

Review 3.  The plant translational apparatus.

Authors:  K S Browning
Journal:  Plant Mol Biol       Date:  1996-10       Impact factor: 4.076

4.  Human cytomegalovirus pTRS1 stimulates cap-independent translation.

Authors:  Heather A Vincent; Benjamin Ziehr; Erik M Lenarcic; Nathaniel J Moorman
Journal:  Virology       Date:  2019-08-29       Impact factor: 3.616

5.  Ribavirin is not a functional mimic of the 7-methyl guanosine mRNA cap.

Authors:  Yifei Yan; Yuri Svitkin; Joseph M Lee; Martin Bisaillon; Jerry Pelletier
Journal:  RNA       Date:  2005-08       Impact factor: 4.942

6.  Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP.

Authors:  N Sonenberg; K M Rupprecht; S M Hecht; A J Shatkin
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

7.  Synthesis of murine mammary tumor viral proteins in vitro.

Authors:  G C Sen; J Racevskis; N H Sarkar
Journal:  J Virol       Date:  1981-03       Impact factor: 5.103

8.  Interaction of a limited set of proteins with different mRNAs and protection of 5'-caps against pyrophosphatase digestion in initiation complexes.

Authors:  N Sonenberg; M A Morgan; D Testa; R J Colonno; A J Shatkin
Journal:  Nucleic Acids Res       Date:  1979-09-11       Impact factor: 16.971

9.  The A1 x U72 base pair conserved in eukaryotic initiator tRNAs is important specifically for binding to the eukaryotic translation initiation factor eIF2.

Authors:  D Farruggio; J Chaudhuri; U Maitra; U L RajBhandary
Journal:  Mol Cell Biol       Date:  1996-08       Impact factor: 4.272

Review 10.  The scanning model for translation: an update.

Authors:  M Kozak
Journal:  J Cell Biol       Date:  1989-02       Impact factor: 10.539
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