PURPOSE: To test the hypothesis that aged women with poor ovarian response express an increase on embryo chromosomal alterations when compared to aged women who presented normal response. METHODS: Couples undergoing intracytoplasmic sperm injection cycles with preimplantation genetic screening, were subdivided into two groups: Poor Responder group (n = 34), patients who produced ≤4 oocytes; and Normoresponder group (n = 50), patients who produced ≥5 oocytes. Groups were compared regarding cycles' outcomes and aneuploidy frequency. RESULTS: There were no significant differences between and groups regarding the fertilization rate (p = 0.6861), clinical pregnancy (p = 0.9208), implantation (p = 0.6863), miscarriage (p = 0.6788) and the percentage of aneuploid embryos (p = 0.270). Embryo transfer rate was significantly lower on poor responder group (p = 0.0128) and logistic regression confirmed the influence of poor response on the chance of embryo transfer (p = 0.016). CONCLUSIONS: Aged females responding poorly to gonadotrophins are not at a higher risk for producing aneuploid embryos in vitro.
PURPOSE: To test the hypothesis that aged women with poor ovarian response express an increase on embryo chromosomal alterations when compared to aged women who presented normal response. METHODS: Couples undergoing intracytoplasmic sperm injection cycles with preimplantation genetic screening, were subdivided into two groups: Poor Responder group (n = 34), patients who produced ≤4 oocytes; and Normoresponder group (n = 50), patients who produced ≥5 oocytes. Groups were compared regarding cycles' outcomes and aneuploidy frequency. RESULTS: There were no significant differences between and groups regarding the fertilization rate (p = 0.6861), clinical pregnancy (p = 0.9208), implantation (p = 0.6863), miscarriage (p = 0.6788) and the percentage of aneuploid embryos (p = 0.270). Embryo transfer rate was significantly lower on poor responder group (p = 0.0128) and logistic regression confirmed the influence of poor response on the chance of embryo transfer (p = 0.016). CONCLUSIONS: Aged females responding poorly to gonadotrophins are not at a higher risk for producing aneuploid embryos in vitro.
Authors: S Ziebe; K Lundin; A Loft; C Bergh; A Nyboe Andersen; U Selleskog; D Nielsen; C Grøndahl; H Kim; J-C Arce Journal: Hum Reprod Date: 2003-12 Impact factor: 6.918
Authors: H Van de Velde; A De Vos; K Sermon; C Staessen; M De Rycke; E Van Assche; W Lissens; M Vandervorst; H Van Ranst; I Liebaers; A Van Steirteghem Journal: Prenat Diagn Date: 2000-12 Impact factor: 3.050
Authors: C Staessen; H Tournaye; E Van Assche; A Michiels; L Van Landuyt; P Devroey; I Liebaers; A Van Steirteghem Journal: Hum Reprod Update Date: 2003 Jul-Aug Impact factor: 15.610