Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Combinatorial alanine substitution enables rapid optimization of cytochrome P450BM3 for selective hydroxylation of large substrates.

Literature DB >> 21108271

Combinatorial alanine substitution enables rapid optimization of cytochrome P450BM3 for selective hydroxylation of large substrates.

Jared C Lewis¹, Simone M Mantovani, Yu Fu, Christopher D Snow, Russell S Komor, Chi-Huey Wong, Frances H Arnold.

Abstract

Entities: CellLine Chemical Disease Mutation Species

Mesh：

Substances：

Year: 2010 PMID： 21108271 PMCID： PMC4447097 DOI： 10.1002/cbic.201000565

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

× No keyword cloud information.

14 in total

1. Assessing the performance of OMEGA with respect to retrieving bioactive conformations.

Authors: Jonas Boström; Jeremy R Greenwood; Johan Gottfries
Journal: J Mol Graph Model Date: 2003-03 Impact factor: 2.518

2. THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

Authors: T OMURA; R SATO
Journal: J Biol Chem Date: 1964-07 Impact factor: 5.157

3. Identification of critical residues in novel drug metabolizing mutants of cytochrome P450 BM3 using random mutagenesis.

Authors: Barbara M A van Vugt-Lussenburg; Eva Stjernschantz; Jeroen Lastdrager; Chris Oostenbrink; Nico P E Vermeulen; Jan N M Commandeur
Journal: J Med Chem Date: 2007-02-08 Impact factor: 7.446

4. General Transition-State Force Field for Cytochrome P450 Hydroxylation.

Authors: Patrik Rydberg; Lars Olsen; Per-Ola Norrby; Ulf Ryde
Journal: J Chem Theory Comput Date: 2007-09 Impact factor: 6.006

5. Towards preparative scale steroid hydroxylation with cytochrome P450 monooxygenase CYP106A2.

Authors: Daniela Zehentgruber; Frank Hannemann; Sabrina Bleif; Rita Bernhardt; Stephan Lütz
Journal: Chembiochem Date: 2010-03-22 Impact factor: 3.164

6. Efficient N-demethylation of opiate alkaloids using a modified nonclassical Polonovski reaction.

Authors: Kristy McCamley; Justin A Ripper; Robert D Singer; Peter J Scammells
Journal: J Org Chem Date: 2003-12-12 Impact factor: 4.354

7. Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450BM3 demethylases.

Authors: Jared C Lewis; Sabine Bastian; Clay S Bennett; Yu Fu; Yuuichi Mitsuda; Mike M Chen; William A Greenberg; Chi-Huey Wong; Frances H Arnold
Journal: Proc Natl Acad Sci U S A Date: 2009-09-15 Impact factor: 11.205

Review 8. Directed enzyme evolution: climbing fitness peaks one amino acid at a time.

Authors: Cara A Tracewell; Frances H Arnold
Journal: Curr Opin Chem Biol Date: 2009-02-25 Impact factor: 8.822

9. Phylogenetic analysis of Bacillus P450 monooxygenases and evaluation of their activity towards steroids.

Authors: Toshiki Furuya; Daisuke Shibata; Kuniki Kino
Journal: Steroids Date: 2009-06-25 Impact factor: 2.668

Review 10. Flavocytochrome P450 BM3: an update on structure and mechanism of a biotechnologically important enzyme.

Authors: A J Warman; O Roitel; R Neeli; H M Girvan; H E Seward; S A Murray; K J McLean; M G Joyce; H Toogood; R A Holt; D Leys; N S Scrutton; A W Munro
Journal: Biochem Soc Trans Date: 2005-08 Impact factor: 5.407

25 in total

1. Combinatorial reshaping of the Candida antarctica lipase A substrate pocket for enantioselectivity using an extremely condensed library.

Authors: Anders G Sandström; Ylva Wikmark; Karin Engström; Jonas Nyhlén; Jan-E Bäckvall
Journal: Proc Natl Acad Sci U S A Date: 2011-12-16 Impact factor: 11.205

2. Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution.

Authors: Sabrina Kille; Felipe E Zilly; Juan P Acevedo; Manfred T Reetz
Journal: Nat Chem Date: 2011-08-14 Impact factor: 24.427

3. Improving the stability and catalyst lifetime of the halogenase RebH by directed evolution.

Authors: Catherine B Poor; Mary C Andorfer; Jared C Lewis
Journal: Chembiochem Date: 2014-05-21 Impact factor: 3.164

Review 4. Controlling substrate specificity and product regio- and stereo-selectivities of P450 enzymes without mutagenesis.

Authors: Vanja Polic; Karine Auclair
Journal: Bioorg Med Chem Date: 2014-06-25 Impact factor: 3.641