INTRODUCTION AND HYPOTHESIS: The purpose of this study is to determine the effect of silver coating of polypropylene implants on infection in hernia surgery. METHODS: Silver-coated and non-silver-coated large pore monofilament polypropylene mesh implants were compared with and without infection (four groups). The implants were inserted in the abdominal wall of female Wistar rats. An Escherichia coli strain was inoculated intraoperatively in the two infected groups. The implants were removed, and clinical, bacteriological, and histological analyses were performed at 2, 15, and 30 days postoperatively. RESULTS: Eighty-four rats were studied. All inoculated rats (n = 21) in the non-silver-coated polypropylene group presented periprosthetic E. coli infection, compared with only five inoculated rats in the silver-coated polypropylene group (p < 0.0001). Erosion was significantly higher in the infected than in the non-infected silver-coated polypropylene groups (p < 0.01). There was no histological difference between the four groups. CONCLUSIONS: Silver-coated implants appear effective against bacterial infection in our rat model, with good histological tolerance but delayed healing.
INTRODUCTION AND HYPOTHESIS: The purpose of this study is to determine the effect of silver coating of polypropylene implants on infection in hernia surgery. METHODS:Silver-coated and non-silver-coated large pore monofilament polypropylene mesh implants were compared with and without infection (four groups). The implants were inserted in the abdominal wall of female Wistar rats. An Escherichia coli strain was inoculated intraoperatively in the two infected groups. The implants were removed, and clinical, bacteriological, and histological analyses were performed at 2, 15, and 30 days postoperatively. RESULTS: Eighty-four rats were studied. All inoculated rats (n = 21) in the non-silver-coated polypropylene group presented periprosthetic E. coli infection, compared with only five inoculated rats in the silver-coated polypropylene group (p < 0.0001). Erosion was significantly higher in the infected than in the non-infected silver-coated polypropylene groups (p < 0.01). There was no histological difference between the four groups. CONCLUSIONS:Silver-coated implants appear effective against bacterial infection in our rat model, with good histological tolerance but delayed healing.
Authors: Loïc Boulanger; Malik Boukerrou; Chrystèle Rubod; Pierre Collinet; A Fruchard; René J Courcol; Michel Cosson Journal: Int Urogynecol J Pelvic Floor Dysfunct Date: 2008-06
Authors: Fang Zheng; Yuan Lin; Eric Verbeken; Filip Claerhout; Maxime Fastrez; Dirk De Ridder; Jan Deprest Journal: Am J Obstet Gynecol Date: 2004-12 Impact factor: 8.661
Authors: P K Sand; S Koduri; R W Lobel; H A Winkler; J Tomezsko; P J Culligan; R Goldberg Journal: Am J Obstet Gynecol Date: 2001-06 Impact factor: 8.661
Authors: T Hernández-Richter; H M Schardey; F Wittmann; S Mayr; M Schmitt-Sody; S Blasenbreu; M M Heiss; C Gabka; M K Angele Journal: Eur J Vasc Endovasc Surg Date: 2003-11 Impact factor: 7.069
Authors: O Guillaume; B Pérez Kohler; R Fortelny; H Redl; F Moriarty; R G Richards; D Eglin; A Petter Puchner Journal: Hernia Date: 2018-08-28 Impact factor: 4.739
Authors: Matthew T Wolf; Christopher A Carruthers; Christopher L Dearth; Peter M Crapo; Alexander Huber; Olivia A Burnsed; Ricardo Londono; Scott A Johnson; Kerry A Daly; Elizabeth C Stahl; John M Freund; Christopher J Medberry; Lisa E Carey; Alejandro Nieponice; Nicholas J Amoroso; Stephen F Badylak Journal: J Biomed Mater Res A Date: 2013-07-19 Impact factor: 4.396
Authors: Natália Gomes Parizzi; Oscar Ávila Rubini; Silvio Henrique Maia de Almeida; Lais Caetano Ireno; Roger Mitio Tashiro; Victor Hugo Tolotto de Carvalho Journal: Int Braz J Urol Date: 2017 Jul-Aug Impact factor: 1.541