OBJECTIVE: We examined whether dietary intake of isoflavones, lignans, isothiocyanates, antioxidants, or specific foods rich in these compounds is associated with reduced risk of B-cell non-Hodgkin lymphoma (NHL), multiple myeloma (MM), or Hodgkin lymphoma (HL) in a large, prospective cohort of women. METHODS: Between 1995-1996 and 31 December 2007, among 110,215 eligible members of the California Teachers Study cohort, 536 women developed incident B-cell NHL, 104 developed MM, and 34 developed HL. Cox proportional hazards regression, with age as the time scale, was used to estimate adjusted rate ratios (RRs) with 95% confidence intervals (CIs) for risk of lymphoid malignancies. RESULTS: Weak inverse associations with risk of diffuse large B-cell lymphoma were observed for isothiocyanates (RR for ≥12.1 vs. <2.7 mcM/day = 0.67, 95% CI: 0.43-1.05) and an antioxidant index measuring hydroxyl radical absorbance capacity (RR for ≥2.2 vs. <0.9 μM Trolox equiv/g/day = 0.68, 95% CI: 0.42-1.10; p (trend) = 0.08). Risk of other NHL subtypes, overall B-cell NHL, MM, or HL was not generally associated with dietary intake of isoflavones, lignans, isothiocyanates, antioxidants, or major food sources of these compounds. CONCLUSIONS: Isoflavones, lignans, isothiocyanates, and antioxidant compounds are not associated with risk of most B-cell malignancies, but some phytocompounds may decrease the risk of selected subtypes.
OBJECTIVE: We examined whether dietary intake of isoflavones, lignans, isothiocyanates, antioxidants, or specific foods rich in these compounds is associated with reduced risk of B-cell non-Hodgkin lymphoma (NHL), multiple myeloma (MM), or Hodgkin lymphoma (HL) in a large, prospective cohort of women. METHODS: Between 1995-1996 and 31 December 2007, among 110,215 eligible members of the California Teachers Study cohort, 536 women developed incident B-cell NHL, 104 developed MM, and 34 developed HL. Cox proportional hazards regression, with age as the time scale, was used to estimate adjusted rate ratios (RRs) with 95% confidence intervals (CIs) for risk of lymphoid malignancies. RESULTS: Weak inverse associations with risk of diffuse large B-cell lymphoma were observed for isothiocyanates (RR for ≥12.1 vs. <2.7 mcM/day = 0.67, 95% CI: 0.43-1.05) and an antioxidant index measuring hydroxyl radical absorbance capacity (RR for ≥2.2 vs. <0.9 μM Trolox equiv/g/day = 0.68, 95% CI: 0.42-1.10; p (trend) = 0.08). Risk of other NHL subtypes, overall B-cell NHL, MM, or HL was not generally associated with dietary intake of isoflavones, lignans, isothiocyanates, antioxidants, or major food sources of these compounds. CONCLUSIONS:Isoflavones, lignans, isothiocyanates, and antioxidant compounds are not associated with risk of most B-cell malignancies, but some phytocompounds may decrease the risk of selected subtypes.
Authors: Pamela L Horn-Ross; Stephen Barnes; Valerie S Lee; Christine N Collins; Peggy Reynolds; Marion M Lee; Susan L Stewart; Alison J Canchola; Landon Wilson; Kenneth Jones Journal: Cancer Causes Control Date: 2006-02 Impact factor: 2.506
Authors: L M Brown; L M Pottern; D T Silverman; J B Schoenberg; A G Schwartz; R S Greenberg; R B Hayes; J M Liff; G M Swanson; R Hoover Journal: Cancer Causes Control Date: 1997-07 Impact factor: 2.506
Authors: B C Chiu; J R Cerhan; A R Folsom; T A Sellers; L H Kushi; R B Wallace; W Zheng; J D Potter Journal: JAMA Date: 1996-05-01 Impact factor: 56.272
Authors: Harold E Seifried; Sharon S McDonald; Darrell E Anderson; Peter Greenwald; John A Milner Journal: Cancer Res Date: 2003-08-01 Impact factor: 12.701
Authors: Sabine Rohrmann; Nikolaus Becker; Jakob Linseisen; Alexandra Nieters; Thomas Rüdiger; Ole Raaschou-Nielsen; Anne Tjønneland; Hans E Johnsen; Kim Overvad; Rudolf Kaaks; Manuela M Bergmann; Heiner Boeing; Vasiliki Benetou; Theodora Psaltopoulou; Antonia Trichopoulou; Giovanna Masala; Amalia Mattiello; Vittorio Krogh; Rosario Tumino; Carla H van Gils; Petra H M Peeters; H Bas Bueno-de-Mesquita; Martine M Ros; Eiliv Lund; Eva Ardanaz; María-Dolores Chirlaque; Paula Jakszyn; Nerea Larrañaga; A Losada; Carmen Martínez-García; Asa Agren; Göran Hallmans; Göran Berglund; Jonas Manjer; Naomi E Allen; Timothy J Key; Sheila Bingham; Kay Tee Khaw; Nadia Slimani; Pietro Ferrari; Paolo Boffetta; Teresa Norat; Paolo Vineis; Elio Riboli Journal: Cancer Causes Control Date: 2007-04-18 Impact factor: 2.506
Authors: Shernan G Holtan; Helen M O'Connor; Zachary S Fredericksen; Mark Liebow; Carrie A Thompson; William R Macon; Ivana N Micallef; Alice H Wang; Susan L Slager; Thomas M Habermann; Timothy G Call; James R Cerhan Journal: Int J Cancer Date: 2011-11-30 Impact factor: 7.396
Authors: Mara M Epstein; Ellen T Chang; Yawei Zhang; Teresa T Fung; Julie L Batista; Richard F Ambinder; Tongzhang Zheng; Nancy E Mueller; Brenda M Birmann Journal: Am J Epidemiol Date: 2015-07-15 Impact factor: 4.897
Authors: Nicholas J Ollberding; Gertraud Maskarinec; Shannon M Conroy; Yukiko Morimoto; Adrian A Franke; Robert V Cooney; Lynne R Wilkens; Loïc Le Marchand; Marc T Goodman; Brenda Y Hernandez; Brian E Henderson; Laurence N Kolonel Journal: Blood Date: 2012-05-01 Impact factor: 22.113
Authors: José Carlos Flores; Esther Gracia-Lavedan; Yolanda Benavente; Pilar Amiano; Dora Romaguera; Laura Costas; Claudia Robles; Eva Gonzalez-Barca; Esmeralda de la Banda; Esther Alonso; Marta Aymerich; Elias Campo; Trinidad Dierssen-Sotos; Rafael Marcos-Gragera; Marta María Rodriguez-Suarez; Marta Solans; Eva Gimeno; Paloma Garcia Martin; Nuria Aragones; Nitin Shivappa; James R Hébert; Marina Pollan; Manolis Kogevinas; Silvia de Sanjose; Gemma Castaño-Vinyals; Delphine Casabonne Journal: Nutrients Date: 2019-12-23 Impact factor: 5.717
Authors: Sophia S Wang; Jenna Voutsinas; Ellen T Chang; Christina A Clarke; Yani Lu; Huiyan Ma; Dee West; James V Lacey; Leslie Bernstein Journal: Cancer Causes Control Date: 2013-04-09 Impact factor: 2.532