Literature DB >> 21107653

A simple reverse genetics approach to elucidating the biosynthetic pathway of nocathiacin.

Maochen Wei1, Jing Deng, Shuzhen Wang, Nan Liu, Yijun Chen.   

Abstract

Genomic library screening and genome mining are currently employed to identify biosynthetic gene clusters of thiopeptides. To elucidate the biosynthetic pathway of nocathiacin, we present a new approach with the application of simple reverse genetics. A relationship between structural features of thiopeptides and their biosynthetic pathways is established and is a starting point for speedily elucidating biosynthetic genes of various ribosomally-synthesized bioactive peptides with diverse modifications.

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Year:  2010        PMID： 21107653     DOI： 10.1007/s10529-010-0460-0

Source DB:  PubMed          Journal:  Biotechnol Lett        ISSN： 0141-5492            Impact factor:   2.461


  5 in total

Review 1.  Thiazole/oxazole-modified microcins: complex natural products from ribosomal templates.

Authors:  Joel O Melby; Nathan J Nard; Douglas A Mitchell
Journal:  Curr Opin Chem Biol       Date:  2011-03-21       Impact factor: 8.822

2.  Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans.

Authors:  Travis S Young; Christopher T Walsh
Journal:  Proc Natl Acad Sci U S A       Date:  2011-07-25       Impact factor: 11.205

3.  Reconstitution and Substrate Specificity of the Radical S-Adenosyl-methionine Thiazole C-Methyltransferase in Thiomuracin Biosynthesis.

Authors:  Nilkamal Mahanta; Zhengan Zhang; Graham A Hudson; Wilfred A van der Donk; Douglas A Mitchell
Journal:  J Am Chem Soc       Date:  2017-03-21       Impact factor: 15.419

Review 4.  YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function.

Authors:  Brandon J Burkhart; Christopher J Schwalen; Greg Mann; James H Naismith; Douglas A Mitchell
Journal:  Chem Rev       Date:  2017-03-03       Impact factor: 60.622

Review 5.  Thiopeptide antibiotics: retrospective and recent advances.

Authors:  Xavier Just-Baringo; Fernando Albericio; Mercedes Álvarez
Journal:  Mar Drugs       Date:  2014-01-17       Impact factor: 5.118
  5 in total

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