Literature DB >> 21107346

Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases.

Jane Hoyt Buckner1.   

Abstract

A lack of regulatory T (T(Reg)) cells that express CD4, CD25 and forkhead box P3 (FOXP3) results in severe autoimmunity in both mice and humans. Since the discovery of T(Reg) cells, there has been intense investigation aimed at determining how they protect an organism from autoimmunity and whether defects in their number or function contribute to the development of autoimmunity in model systems. The next phase of investigation - that is, to define the role that defects in T(Reg) cells have in human autoimmunity - is now underway. This Review summarizes our progress so far towards understanding the role of CD4(+)CD25(+)FOXP3(+) T(Reg) cells in human autoimmune diseases and the impact that this knowledge might have on the diagnosis and treatment of these diseases.

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Year:  2010        PMID： 21107346      PMCID： PMC3046807          DOI： 10.1038/nri2889

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


  119 in total

1.  Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells.

Authors:  Chandrashekhar Pasare; Ruslan Medzhitov
Journal:  Science       Date:  2003-01-16       Impact factor: 47.728

2.  Control of regulatory T cell development by the transcription factor Foxp3.

Authors:  Shohei Hori; Takashi Nomura; Shimon Sakaguchi
Journal:  Science       Date:  2003-01-09       Impact factor: 47.728

3.  CD4+CD25high regulatory cells in human peripheral blood.

Authors:  C Baecher-Allan; J A Brown; G J Freeman; D A Hafler
Journal:  J Immunol       Date:  2001-08-01       Impact factor: 5.422

4.  Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells.

Authors:  H L Weiner
Journal:  Immunol Rev       Date:  2001-08       Impact factor: 12.988

5.  Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro.

Authors:  L A Stephens; C Mottet; D Mason; F Powrie
Journal:  Eur J Immunol       Date:  2001-04       Impact factor: 5.532

6.  Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.

Authors:  M E Brunkow; E W Jeffery; K A Hjerrild; B Paeper; L B Clark; S A Yasayko; J E Wilkinson; D Galas; S F Ziegler; F Ramsdell
Journal:  Nat Genet       Date:  2001-01       Impact factor: 38.330

7.  Multiple immuno-regulatory defects in type-1 diabetes.

Authors:  Anjli Kukreja; Giulia Cost; John Marker; Chenhui Zhang; Zhong Sun; Karen Lin-Su; Svetlana Ten; Maureen Sanz; Mark Exley; Brian Wilson; Steven Porcelli; Noel Maclaren
Journal:  J Clin Invest       Date:  2002-01       Impact factor: 14.808

Review 8.  Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome.

Authors:  R S Wildin; S Smyk-Pearson; A H Filipovich
Journal:  J Med Genet       Date:  2002-08       Impact factor: 6.318

9.  Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells.

Authors:  Leonie S Taams; Milica Vukmanovic-Stejic; Jay Smith; Padraic J Dunne; Jean M Fletcher; Fiona J Plunkett; Saskia B Ebeling; Giovanna Lombardi; Malcolm H Rustin; Johannes W J Bijlsma; Floris P J G Lafeber; Mike Salmon; Arne N Akbar
Journal:  Eur J Immunol       Date:  2002-06       Impact factor: 5.532

10.  Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis.

Authors:  Adam P Kohm; Pamela A Carpentier; Holly A Anger; Stephen D Miller
Journal:  J Immunol       Date:  2002-11-01       Impact factor: 5.422
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  299 in total

Review 1.  Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions.

Authors:  Mario Delgado; Doina Ganea
Journal:  Amino Acids       Date:  2011-12-03       Impact factor: 3.520

2.  B cell depletion enhances T regulatory cell activity essential in the suppression of arthritis.

Authors:  Keith M Hamel; Yanxia Cao; Susan Ashaye; Yumei Wang; Robert Dunn; Marilyn R Kehry; Tibor T Glant; Alison Finnegan
Journal:  J Immunol       Date:  2011-09-23       Impact factor: 5.422

Review 3.  Regulatory T cell migration during an immune response.

Authors:  Yaozhong Ding; Jiangnan Xu; Jonathan S Bromberg
Journal:  Trends Immunol       Date:  2012-02-02       Impact factor: 16.687

4.  Non-suppressive regulatory T cell subset expansion in pulmonary arterial hypertension.

Authors:  Yoshiharu Sada; Yoshihiro Dohi; Sayuri Uga; Akifumi Higashi; Hiroki Kinoshita; Yasuki Kihara
Journal:  Heart Vessels       Date:  2015-08-29       Impact factor: 2.037

5.  Overexpression of CD45RA isoforms in carriers of the C77G mutation leads to hyporeactivity of CD4+CD25highFoxp3+ regulatory T cells.

Authors:  C Pokoyski; T Lienen; S Rother; E Schock; A Plege-Fleck; R Geffers; R Schwinzer
Journal:  Genes Immun       Date:  2015-09-10       Impact factor: 2.676

6.  The CD137 Ligand Is Important for Type 1 Diabetes Development but Dispensable for the Homeostasis of Disease-Suppressive CD137+ FOXP3+ Regulatory CD4 T Cells.

Authors:  Bardees M Foda; Ashley E Ciecko; David V Serreze; William M Ridgway; Aron M Geurts; Yi-Guang Chen
Journal:  J Immunol       Date:  2020-04-15       Impact factor: 5.422

Review 7.  Emerging cell and cytokine targets in rheumatoid arthritis.

Authors:  Gerd R Burmester; Eugen Feist; Thomas Dörner
Journal:  Nat Rev Rheumatol       Date:  2013-11-12       Impact factor: 20.543

8.  Coexpression of TIGIT and FCRL3 identifies Helios+ human memory regulatory T cells.

Authors:  Khalid Bin Dhuban; Eva d'Hennezel; Emil Nashi; Amit Bar-Or; Sadiye Rieder; Ethan M Shevach; Satoshi Nagata; Ciriaco A Piccirillo
Journal:  J Immunol       Date:  2015-03-11       Impact factor: 5.422

9.  Extracellular Vesicles: Evolving Contributors in Autoimmunity.

Authors:  Stergios Katsiougiannis
Journal:  For Immunopathol Dis Therap       Date:  2015

10.  METEORIN-LIKE is a cytokine associated with barrier tissues and alternatively activated macrophages.

Authors:  Irina Ushach; Amanda M Burkhardt; Cynthia Martinez; Peter A Hevezi; Peter Arne Gerber; Bettina Alexandra Buhren; Holger Schrumpf; Ricardo Valle-Rios; Monica I Vazquez; Bernhard Homey; Albert Zlotnik
Journal:  Clin Immunol       Date:  2014-12-05       Impact factor: 3.969
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