Literature DB >> 22139413

Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions.

Mario Delgado1, Doina Ganea.   

Abstract

Vasoactive intestinal peptide (VIP), a 28-amino acid neuropeptide/neurotransmitter, is widely distributed in both the central and peripheral nervous system. VIP is released by both neurons and immune cells. Various cell types, including immune cells, express VIP receptors. VIP has pleiotropic effects as a neurotransmitter, immune regulator, vasodilator and secretagogue. This review is focused on VIP production and effects on immune cells, VIP receptor signaling as related to immune functions, and the involvement of VIP in inflammatory and autoimmune disorders. The review addresses present clinical use of VIP and future therapeutic directions.

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Year:  2011        PMID： 22139413      PMCID： PMC3883350          DOI： 10.1007/s00726-011-1184-8

Source DB:  PubMed          Journal:  Amino Acids        ISSN： 0939-4451            Impact factor:   3.520


  124 in total

Review 1.  How tolerogenic dendritic cells induce regulatory T cells.

Authors:  Roberto A Maldonado; Ulrich H von Andrian
Journal:  Adv Immunol       Date:  2010       Impact factor: 3.543

2.  Vasoactive intestinal peptide generates human tolerogenic dendritic cells that induce CD4 and CD8 regulatory T cells.

Authors:  Elena Gonzalez-Rey; Alejo Chorny; Amelia Fernandez-Martin; Doina Ganea; Mario Delgado
Journal:  Blood       Date:  2006-01-05       Impact factor: 22.113

3.  Vasoactive intestinal peptide loss leads to impaired CNS parenchymal T-cell infiltration and resistance to experimental autoimmune encephalomyelitis.

Authors:  Catalina Abad; Yossan-Var Tan; Robert Lopez; Hiroko Nobuta; Hongmei Dong; Phu Phan; Ji-Ming Feng; Anthony T Campagnoni; James A Waschek
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-26       Impact factor: 11.205

4.  Neuropeptides kill African trypanosomes by targeting intracellular compartments and inducing autophagic-like cell death.

Authors:  M Delgado; P Anderson; J A Garcia-Salcedo; M Caro; E Gonzalez-Rey
Journal:  Cell Death Differ       Date:  2008-12-05       Impact factor: 15.828

Review 5.  VPAC and PAC receptors: From ligands to function.

Authors:  Louise Dickson; Keith Finlayson
Journal:  Pharmacol Ther       Date:  2008-12-06       Impact factor: 12.310

6.  Treating men with predominantly nonpsychogenic erectile dysfunction with intracavernosal vasoactive intestinal polypeptide and phentolamine mesylate in a novel auto-injector system: a multicentre double-blind placebo-controlled study.

Authors:  W W Dinsmore; C Gingell; G Hackett; P Kell; D Savage; R Oakes; G D Frentz
Journal:  BJU Int       Date:  1999-02       Impact factor: 5.588

7.  New insights into the role of VIP on the ratio of T-cell subsets during the development of autoimmune diabetes.

Authors:  Rebeca Jimeno; Rosa P Gomariz; Irene Gutiérrez-Cañas; Carmen Martínez; Yasmina Juarranz; Javier Leceta
Journal:  Immunol Cell Biol       Date:  2010-03-23       Impact factor: 5.126

8.  Inhalable powder formulation of vasoactive intestinal peptide derivative, [R15,20,21, L17]-VIP-GRR, attenuated neutrophilic airway inflammation in cigarette smoke-exposed rats.

Authors:  Satomi Onoue; Shingen Misaka; Yosuke Aoki; Shin-ichiro Karaki; Atsukazu Kuwahara; Asami Ohide; Takahiro Mizumoto; Shizuo Yamada
Journal:  Eur J Pharm Sci       Date:  2010-08-24       Impact factor: 4.384

9.  Regulatory effect of vasoactive intestinal peptide on the balance of Treg and Th17 in collagen-induced arthritis.

Authors:  Shaohua Deng; Yebin Xi; Hong Wang; Jing Hao; Xiaoyin Niu; Weiyi Li; Yue Tao; Guangjie Chen
Journal:  Cell Immunol       Date:  2010-07-30       Impact factor: 4.868

10.  Protective effect of intravitreal injection of vasoactive intestinal peptide-loaded liposomes on experimental autoimmune uveoretinitis.

Authors:  Serge Camelo; Laure Lajavardi; Amélie Bochot; Brigitte Goldenberg; Marie-Christine Naud; Nadège Brunel; Bernadette Lescure; Christophe Klein; Elias Fattal; Francine Behar-Cohen; Yvonne de Kozak
Journal:  J Ocul Pharmacol Ther       Date:  2009-02       Impact factor: 2.671
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  51 in total

1.  Pancreatic Tumor Presenting as Diarrhea.

Authors:  Kalpit Devani; Dhara Chaudhari; Mark Young
Journal:  J Gastrointest Cancer       Date:  2016-12

2.  Administration of a vasoactive intestinal peptide antagonist enhances the autologous anti-leukemia T cell response in murine models of acute leukemia.

Authors:  Christopher T Petersen; Jian-Ming Li; Edmund K Waller
Journal:  Oncoimmunology       Date:  2017-03-16       Impact factor: 8.110

Review 3.  Resident macrophages in the healthy and inflamed intestinal muscularis externa.

Authors:  Sven Wehner; Daniel Robert Engel
Journal:  Pflugers Arch       Date:  2017-02-24       Impact factor: 3.657

4.  Influence of renovascular hypertension on the distribution of vasoactive intestinal peptide in the stomach and heart of rats.

Authors:  Irena Kasacka; Żaneta Piotrowska; Izabela Janiuk
Journal:  Exp Biol Med (Maywood)       Date:  2015-05-19

5.  Vasoactive Intestinal Peptide Promotes Corneal Allograft Survival.

Authors:  Vannarut Satitpitakul; Zhongmou Sun; Kunal Suri; Afsaneh Amouzegar; Kishore R Katikireddy; Ula V Jurkunas; Ahmad Kheirkhah; Reza Dana
Journal:  Am J Pathol       Date:  2018-08-07       Impact factor: 4.307

6.  Vasoactive intestinal peptide suppresses macrophage-mediated inflammation by downregulating interleukin-17A expression via PKA- and PKC-dependent pathways.

Authors:  Wen-Zhuo Ran; Liang Dong; Chun-Yan Tang; Yong Zhou; Guo-Ying Sun; Tian Liu; Yong-Ping Liu; Cha-Xiang Guan
Journal:  Int J Exp Pathol       Date:  2015-05-05       Impact factor: 1.925

Review 7.  Neuro-immune crosstalk and allergic inflammation.

Authors:  Hiroki Kabata; David Artis
Journal:  J Clin Invest       Date:  2019-03-04       Impact factor: 14.808

Review 8.  Immunomodulation as a neuroprotective and therapeutic strategy for Parkinson's disease.

Authors:  Katherine E Olson; Howard E Gendelman
Journal:  Curr Opin Pharmacol       Date:  2015-11-11       Impact factor: 5.547

9.  Effect of baicalein on the expression of VIP in extravillous cytotrophoblasts infected with human cytomegalovirus in vitro.

Authors:  Yuan Qiao; Jian-Guo Fang; Juan Xiao; Tao Liu; Jing Liu; Yan-Li Zhang; Su-Hua Chen
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2013-06-17

10.  Effect of vasoactive intestinal peptide on the wound healing of alkali-burned corneas.

Authors:  Nese Tuncel; Nilgun Yildirim; Firdevs Gurer; Hikmet Basmak; Kubilay Uzuner; Varol Sahinturk; Huseyin Gursoy
Journal:  Int J Ophthalmol       Date:  2016-02-18       Impact factor: 1.779
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