Literature DB >> 21106452

Synthesis and anti-HCV activity of a new 2'-deoxy-2'-fluoro-2'-C-methyl nucleoside analogue.

Weidong Hu1, Ping'an Wang, Chuanjun Song, Zhenliang Pan, Qiang Wang, Xiaohe Guo, Xuejun Yu, Zhenhua Shen, Shuyang Wang, Junbiao Chang.   

Abstract

2'-Deoxy-2'-fluoro-2'-C-methyl nucleoside analogue 4 was designed and synthesized. Initial biological studies indicated that this compound showed promising activity against HCV replication.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 21106452     DOI： 10.1016/j.bmcl.2010.10.076

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Synthesis and anti-HBV activity of carbocyclic nucleoside hybrids with salient features of entecavir and aristeromycin.

Authors:  Ramakrishnamraju Samunuri; Masaaki Toyama; Renuka Sivasankar Pallaka; Seshubabu Neeladri; Ashok Kumar Jha; Masanori Baba; Chandralata Bal
Journal:  RSC Med Chem       Date:  2020-05-15

2.  Synthesis of 7-trifluoromethyl-7-deazapurine ribonucleoside analogs and their monophosphate prodrugs.

Authors:  Jong Hyun Cho; Leda C Bassit; Franck Amblard; Raymond F Schinazi
Journal:  Nucleosides Nucleotides Nucleic Acids       Date:  2019-10-07       Impact factor: 1.381

Review 3.  Pyrrolo[2,3-d]pyrimidine (7-deazapurine) as a privileged scaffold in design of antitumor and antiviral nucleosides.

Authors:  Pavla Perlíková; Michal Hocek
Journal:  Med Res Rev       Date:  2017-08-23       Impact factor: 12.944

4.  4-Chloro-1H-pyrrolo-[2,3-d]pyrimidine.

Authors:  Su-Lan Dong; Xiaochun Cheng
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-08-08
  4 in total

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