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Literature DB >> 31588837

Synthesis of 7-trifluoromethyl-7-deazapurine ribonucleoside analogs and their monophosphate prodrugs.

Jong Hyun Cho¹, Leda C Bassit², Franck Amblard², Raymond F Schinazi².

Abstract

Novel 7-trifluoromethyl-7-deazapurine ribonucleoside analogs (13a-c) and their Protides (15a-c) were successfully synthesized from ribolactol or 1-α-bromo-ribose derivatives using Silyl-Hilbert-Johnson or nucleobase-anion substitution reactions followed by key aromatic trifluoromethyl substitution. Newly prepared compounds were evaluated against a panel of RNA viruses, including HCV, Ebola or Zika viruses.

Entities: CellLine Chemical Disease Gene Species

Keywords: 7-trifluoromethyl-7-deazapurine ribonucleoside; RNA viruses; Silyl-Hilbert-Johnson; protides

Mesh：

Substances：

Year: 2019 PMID： 31588837 PMCID： PMC7668401 DOI： 10.1080/15257770.2019.1674333

Source DB: PubMed Journal: Nucleosides Nucleotides Nucleic Acids ISSN： 1525-7770 Impact factor: 1.381

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Synthesis of 7-trifluoromethyl-7-deazapurine ribonucleoside analogs and their monophosphate prodrugs.

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