Literature DB >> 21098241

Diversity of the early step of the futalosine pathway.

Chisato Arakawa1, Masahiro Kuratsu, Kazuo Furihata, Tomoshige Hiratsuka, Nobuya Itoh, Haruo Seto, Tohru Dairi.   

Abstract

We recently demonstrated that the futalosine pathway was operating in some bacteria for the biosynthesis of menaquinone and that futalosine was converted into dehypoxanthinyl futalosine (DHFL) by an MqnB of Thermus thermophilus. In this study, we found that aminodeoxyfutalosine, which has adenine instead of hypoxanthine in futalosine, was directly converted into DHFL by an MqnB of Helicobacter pylori. Therefore, this step is potentially an attractive target for the development of specific anti-H. pylori drugs.

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Year:  2010        PMID： 21098241      PMCID： PMC3028782          DOI： 10.1128/AAC.01362-10

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  6 in total

1.  The complete genome sequence of the gastric pathogen Helicobacter pylori.

Authors:  J F Tomb; O White; A R Kerlavage; R A Clayton; G G Sutton; R D Fleischmann; K A Ketchum; H P Klenk; S Gill; B A Dougherty; K Nelson; J Quackenbush; L Zhou; E F Kirkness; S Peterson; B Loftus; D Richardson; R Dodson; H G Khalak; A Glodek; K McKenney; L M Fitzegerald; N Lee; M D Adams; E K Hickey; D E Berg; J D Gocayne; T R Utterback; J D Peterson; J M Kelley; M D Cotton; J M Weidman; C Fujii; C Bowman; L Watthey; E Wallin; W S Hayes; M Borodovsky; P D Karp; H O Smith; C M Fraser; J C Venter
Journal:  Nature       Date:  1997-08-07       Impact factor: 49.962

2.  An alternative menaquinone biosynthetic pathway operating in microorganisms.

Authors:  Tomoshige Hiratsuka; Kazuo Furihata; Jun Ishikawa; Haruyuki Yamashita; Nobuya Itoh; Haruo Seto; Tohru Dairi
Journal:  Science       Date:  2008-09-19       Impact factor: 47.728

Review 3.  Biosynthesis of menaquinone (vitamin K2) and ubiquinone (coenzyme Q): a perspective on enzymatic mechanisms.

Authors:  R Meganathan
Journal:  Vitam Horm       Date:  2001       Impact factor: 3.421

4.  Complete genome of the cellulolytic thermophile Acidothermus cellulolyticus 11B provides insights into its ecophysiological and evolutionary adaptations.

Authors:  Ravi D Barabote; Gary Xie; David H Leu; Philippe Normand; Anamaria Necsulea; Vincent Daubin; Claudine Médigue; William S Adney; Xin Clare Xu; Alla Lapidus; Rebecca E Parales; Chris Detter; Petar Pujic; David Bruce; Celine Lavire; Jean F Challacombe; Thomas S Brettin; Alison M Berry
Journal:  Genome Res       Date:  2009-03-06       Impact factor: 9.043

5.  Enzymatic properties of futalosine hydrolase, an enzyme essential to a newly identified menaquinone biosynthetic pathway.

Authors:  Tomoshige Hiratsuka; Nobuya Itoh; Haruo Seto; Tohru Dairi
Journal:  Biosci Biotechnol Biochem       Date:  2009-05-07       Impact factor: 2.043

6.  Studies on a new biosynthetic pathway for menaquinone.

Authors:  Haruo Seto; Yuusuke Jinnai; Tomoshige Hiratsuka; Miwako Fukawa; Kazuo Furihata; Nobuya Itoh; Tohru Dairi
Journal:  J Am Chem Soc       Date:  2008-04-08       Impact factor: 15.419
  6 in total
  16 in total

1.  Refining the phylum Chlorobi by resolving the phylogeny and metabolic potential of the representative of a deeply branching, uncultivated lineage.

Authors:  Jennifer Hiras; Yu-Wei Wu; Stephanie A Eichorst; Blake A Simmons; Steven W Singer
Journal:  ISME J       Date:  2015-09-01       Impact factor: 10.302

2.  Identification of tirandamycins as specific inhibitors of the futalosine pathway.

Authors:  Yasushi Ogasawara; Kensuke Kondo; Ayumi Ikeda; Rikako Harada; Tohru Dairi
Journal:  J Antibiot (Tokyo)       Date:  2017-03-01       Impact factor: 2.649

3.  5'-methylthioadenosine nucleosidase is implicated in playing a key role in a modified futalosine pathway for menaquinone biosynthesis in Campylobacter jejuni.

Authors:  Xu Li; Dmitry Apel; Erin C Gaynor; Martin E Tanner
Journal:  J Biol Chem       Date:  2011-04-13       Impact factor: 5.157

Review 4.  Searching for potent and specific antibiotics against pathogenic Helicobacter and Campylobacter strains.

Authors:  Yasushi Ogasawara; Tohru Dairi
Journal:  J Ind Microbiol Biotechnol       Date:  2018-11-20       Impact factor: 3.346

5.  Menaquinone biosynthesis: formation of aminofutalosine requires a unique radical SAM enzyme.

Authors:  Nilkamal Mahanta; Dmytro Fedoseyenko; Tohru Dairi; Tadhg P Begley
Journal:  J Am Chem Soc       Date:  2013-10-07       Impact factor: 15.419

Review 6.  Enzymatic Transition States and Drug Design.

Authors:  Vern L Schramm
Journal:  Chem Rev       Date:  2018-10-18       Impact factor: 60.622

7.  Deamination of 6-aminodeoxyfutalosine in menaquinone biosynthesis by distantly related enzymes.

Authors:  Alissa M Goble; Rafael Toro; Xu Li; Argentina Ornelas; Hao Fan; Subramaniam Eswaramoorthy; Yury Patskovsky; Brandan Hillerich; Ron Seidel; Andrej Sali; Brian K Shoichet; Steven C Almo; Subramanyam Swaminathan; Martin E Tanner; Frank M Raushel
Journal:  Biochemistry       Date:  2013-09-04       Impact factor: 3.162

8.  The futalosine pathway played an important role in menaquinone biosynthesis during early prokaryote evolution.

Authors:  Xiao-Yang Zhi; Ji-Cheng Yao; Shu-Kun Tang; Ying Huang; Hong-Wei Li; Wen-Jun Li
Journal:  Genome Biol Evol       Date:  2014-01       Impact factor: 3.416

Review 9.  Chlamydia exploit the mammalian tryptophan-depletion defense strategy as a counter-defensive cue to trigger a survival state of persistence.

Authors:  Carol A Bonner; Gerald I Byrne; Roy A Jensen
Journal:  Front Cell Infect Microbiol       Date:  2014-02-28       Impact factor: 5.293

10.  Aminofutalosine Deaminase in the Menaquinone Pathway of Helicobacter pylori.

Authors:  Mu Feng; Rajesh K Harijan; Lawrence D Harris; Peter C Tyler; Richard F G Fröhlich; Morais Brown; Vern L Schramm
Journal:  Biochemistry       Date:  2021-06-02       Impact factor: 3.321
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