OBJECTIVE: Our objective was to compare survival and neonatal morbidity rates between very low birth weight (VLBW) infants with Down syndrome (DS) and VLBW infants with non-DS chromosomal anomalies, nonchromosomal birth defects (BDs), and no chromosomal anomaly or major BD. METHODS: Data were collected prospectively for infants weighing 401 to 1500 g who were born and/or cared for at one of the study centers participating in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network in 1994-2008. Risk of death and morbidities, including patent ductus arteriosus (PDA), necrotizing enterocolitis (NEC), late-onset sepsis (LOS), retinopathy of prematurity, and bronchopulmonary dysplasia (BPD), were compared between VLBW infants with DS and infants in the other groups. RESULTS: Infants with DS were at increased risk of death (adjusted relative risk: 2.47 [95% confidence interval: 2.00-3.07]), PDA, NEC, LOS, and BPD, relative to infants with no BDs. Decreased risk of death (relative risk: 0.40 [95% confidence interval: 0.31-0.52]) and increased risks of NEC and LOS were observed when infants with DS were compared with infants with other non-DS chromosomal anomalies. Relative to infants with nonchromosomal BDs, infants with DS were at increased risk of PDA and NEC. CONCLUSION: The increased risk of morbidities among VLBW infants with DS provides useful information for counseling parents and for anticipating the need for enhanced surveillance for prevention of these morbidities.
OBJECTIVE: Our objective was to compare survival and neonatal morbidity rates between very low birth weight (VLBW) infants with Down syndrome (DS) and VLBW infants with non-DS chromosomal anomalies, nonchromosomal birth defects (BDs), and no chromosomal anomaly or major BD. METHODS: Data were collected prospectively for infants weighing 401 to 1500 g who were born and/or cared for at one of the study centers participating in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network in 1994-2008. Risk of death and morbidities, including patent ductus arteriosus (PDA), necrotizing enterocolitis (NEC), late-onset sepsis (LOS), retinopathy of prematurity, and bronchopulmonary dysplasia (BPD), were compared between VLBW infants with DS and infants in the other groups. RESULTS:Infants with DS were at increased risk of death (adjusted relative risk: 2.47 [95% confidence interval: 2.00-3.07]), PDA, NEC, LOS, and BPD, relative to infants with no BDs. Decreased risk of death (relative risk: 0.40 [95% confidence interval: 0.31-0.52]) and increased risks of NEC and LOS were observed when infants with DS were compared with infants with other non-DS chromosomal anomalies. Relative to infants with nonchromosomal BDs, infants with DS were at increased risk of PDA and NEC. CONCLUSION: The increased risk of morbidities among VLBW infants with DS provides useful information for counseling parents and for anticipating the need for enhanced surveillance for prevention of these morbidities.
Authors: Mark A Canfield; Margaret A Honein; Nataliya Yuskiv; Jian Xing; Cara T Mai; Julianne S Collins; Owen Devine; Joann Petrini; Tunu A Ramadhani; Charlotte A Hobbs; Russell S Kirby Journal: Birth Defects Res A Clin Mol Teratol Date: 2006-11
Authors: D Satgé; A J Sasco; N L Carlsen; C A Stiller; H Rubie; B Hero; B de Bernardi; J de Kraker; C Coze; P Kogner; F Langmark; F G Hakvoort-Cammel; D Beck; N von der Weid; S Parkes; O Hartmann; R J Lippens; W A Kamps; D Sommelet Journal: Cancer Res Date: 1998-02-01 Impact factor: 12.701
Authors: Arin K Greene; Sendia Kim; Gary F Rogers; Steven J Fishman; Bjorn R Olsen; John B Mulliken Journal: Pediatrics Date: 2008-01 Impact factor: 7.124
Authors: Cassandra D Josephson; Traci Heath Mondoro; Daniel R Ambruso; Rosa Sanchez; Steven R Sloan; Naomi L C Luban; John A Widness Journal: Pediatr Res Date: 2014-08-13 Impact factor: 3.756
Authors: Ira Adams-Chapman; Nellie I Hansen; Seetha Shankaran; Edward F Bell; Nansi S Boghossian; Jeffrey C Murray; Abbot R Laptook; Michele C Walsh; Waldemar A Carlo; Pablo J Sánchez; Krisa P Van Meurs; Abhik Das; Ellen C Hale; Nancy S Newman; M Bethany Ball; Rosemary D Higgins; Barbara J Stoll Journal: Pediatrics Date: 2013-06-03 Impact factor: 7.124
Authors: Kathryn Y Burge; Aarthi Gunasekaran; Marjorie M Makoni; Arshid M Mir; Harold M Burkhart; Hala Chaaban Journal: J Clin Med Date: 2022-07-09 Impact factor: 4.964