| Literature DB >> 21095821 |
Igor R Efimov1, Vadim V Fedorov, Alexey Glukhov, Qing Lou, Christina Ambrosi, Deborah Janks, William J Hucker, Thomas Kurian, Richard B Schuessler, Nader Moazami.
Abstract
The development of human cardiovascular systems physiology is inhibited by the lack of multiscale functional physiological data, which represents human heart physiology at the molecular, cellular, tissue, organ, and system levels. We have developed an experimental approach to study explanted human hearts in vitro at multiple physiological scales with a wide array of imaging modalities. This approach has already yielded data indicating significant differences between animal models of diseases and actual human heart disease. Our data provides a quantitative foundation for multiscale physiological models of the cardiovascular system and will allow improvement in translation of medical technology and pharmacology from animal models to therapy.Entities:
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Year: 2010 PMID： 21095821 PMCID： PMC3748588 DOI： 10.1109/IEMBS.2010.5626151
Source DB: PubMed Journal: Annu Int Conf IEEE Eng Med Biol Soc ISSN： 2375-7477