INTRODUCTION: Delayed graft function (DGF) and slow graft function (SGF) due to ischemic and reperfusion injury (IRI) are common complications of deceased donor kidney transplantation. We tested whether a panel of serum and urine cytokines represent early biomarkers for DGF and SGF. METHODS: We collected serum and urine samples from 61 patients 48 hours posttransplantation and used a multiplex enzyme-linked immunosorbent assay (ELISA) technique to measure levels of 23 cytokines. Fourteen patients developed poor graft function (PGF), with 6 having DGF and 8 with SGF. RESULTS: Area under receiver operation characteristics curve (AUC) demonstrated the following: serum levels of SCF (0.88) and interleukin (IL) 16 (0.74). CONCLUSIONS: This study showed that a select panel of cytokines measured early post kidney transplantation may predict poor graft function.
INTRODUCTION: Delayed graft function (DGF) and slow graft function (SGF) due to ischemic and reperfusion injury (IRI) are common complications of deceased donor kidney transplantation. We tested whether a panel of serum and urine cytokines represent early biomarkers for DGF and SGF. METHODS: We collected serum and urine samples from 61 patients 48 hours posttransplantation and used a multiplex enzyme-linked immunosorbent assay (ELISA) technique to measure levels of 23 cytokines. Fourteen patients developed poor graft function (PGF), with 6 having DGF and 8 with SGF. RESULTS: Area under receiver operation characteristics curve (AUC) demonstrated the following: serum levels of SCF (0.88) and interleukin (IL) 16 (0.74). CONCLUSIONS: This study showed that a select panel of cytokines measured early post kidney transplantation may predict poor graft function.
Authors: Ari V Ahola-Olli; Peter Würtz; Aki S Havulinna; Kristiina Aalto; Niina Pitkänen; Terho Lehtimäki; Mika Kähönen; Leo-Pekka Lyytikäinen; Emma Raitoharju; Ilkka Seppälä; Antti-Pekka Sarin; Samuli Ripatti; Aarne Palotie; Markus Perola; Jorma S Viikari; Sirpa Jalkanen; Mikael Maksimow; Veikko Salomaa; Marko Salmi; Johannes Kettunen; Olli T Raitakari Journal: Am J Hum Genet Date: 2016-12-15 Impact factor: 11.025
Authors: W Zhang; L Jia; D L X Liu; L Chen; Q Wang; K Song; S Nie; J Ma; X Chen; M Xiu; M Gao; D Zhao; Y Zheng; S Duan; Z Dong; Z Li; P Wang; B Fu; G Cai; X Sun; X Chen Journal: J Nutr Health Aging Date: 2019 Impact factor: 4.075
Authors: J Levitsky; D R Salomon; M Abecassis; P Langfelder; S Horvath; J Friedewald; E Wang; S M Kurian; T Mondala; S Gil; R McDade; K Ballard; L Gallon Journal: Am J Transplant Date: 2011-07-27 Impact factor: 8.086