Liu Jia1, Shen Jia-Lin, Dong Qin, Lu Qing, Zhou Yan. 1. Department of Radiology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.
Abstract
BACKGROUND AND PURPOSE: Essential tremor (ET) is suggested to be a neural degenerative disease. The authors investigated the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) value in basal ganglia, thalamus, red nucleus, and substantia nigra in ET patients using diffusion tensor image (DTI). METHODS: DTI examination was carried out in patients with ET and controls. FA and ADC values were obtained from various brain structures, including caudate, putamen+pallidum, thalamus, red nucleus, and substantia nigra. RESULTS: The ADC value of the red nuclei in patients with ET was higher compared with controls (.90 vs .77; P= .000). However, no significant differences were demonstrated for FA, or ADC values of other structures. CONCLUSIONS: The increased ADC value in the red nucleus indicates that there is neuronal damage or loss present, suggesting that ET may be a neurodegenerative disease.
BACKGROUND AND PURPOSE: Essential tremor (ET) is suggested to be a neural degenerative disease. The authors investigated the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) value in basal ganglia, thalamus, red nucleus, and substantia nigra in ET patients using diffusion tensor image (DTI). METHODS: DTI examination was carried out in patients with ET and controls. FA and ADC values were obtained from various brain structures, including caudate, putamen+pallidum, thalamus, red nucleus, and substantia nigra. RESULTS: The ADC value of the red nuclei in patients with ET was higher compared with controls (.90 vs .77; P= .000). However, no significant differences were demonstrated for FA, or ADC values of other structures. CONCLUSIONS: The increased ADC value in the red nucleus indicates that there is neuronal damage or loss present, suggesting that ET may be a neurodegenerative disease.
Authors: Pejman Ghanouni; Kim Butts Pauly; W Jeff Elias; Jaimie Henderson; Jason Sheehan; Stephen Monteith; Max Wintermark Journal: AJR Am J Roentgenol Date: 2015-07 Impact factor: 3.959
Authors: Christopher W Hess; Edward Ofori; Umer Akbar; Michael S Okun; David E Vaillancourt Journal: Curr Neurol Neurosci Rep Date: 2013-11 Impact factor: 5.081
Authors: Arthur W G Buijink; Matthan W A Caan; Marina A J Tijssen; Johannes M Hoogduin; Natasha M Maurits; Anne-Fleur van Rootselaar Journal: Cerebellum Date: 2013-04 Impact factor: 3.847
Authors: Arnab Roy; Stephen A Coombes; Jae Woo Chung; Derek B Archer; Michael S Okun; Christopher W Hess; Aparna Wagle Shukla; David E Vaillancourt Journal: Mov Disord Date: 2018-10-21 Impact factor: 10.338