Literature DB >> 21091656

Pregnane X receptor- and CYP3A4-humanized mouse models and their applications.

Jie Cheng1, Xiaochao Ma, Frank J Gonzalez.   

Abstract

Pregnane X receptor (PXR) is a pivotal nuclear receptor modulating xenobiotic metabolism primarily through its regulation of CYP3A4, the most important enzyme involved in drug metabolism in humans. Due to the marked species differences in ligand recognition by PXR, PXR-humanized (hPXR) mice, and mice expressing human PXR and CYP3A4 (Tg3A4/hPXR) were established. hPXR and Tg3A4/hPXR mice are valuable models for investigating the role of PXR in xenobiotic metabolism and toxicity, in lipid, bile acid and steroid hormone homeostasis, and in the control of inflammation. British Journal of Pharmacology
© 2011 The British Pharmacological Society. No claim to original US government works.

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Year:  2011        PMID： 21091656      PMCID： PMC3101609          DOI： 10.1111/j.1476-5381.2010.01129.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  51 in total

1.  A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4.

Authors:  Xiaochao Ma; Connie Cheung; Kristopher W Krausz; Yatrik M Shah; Ting Wang; Jeffrey R Idle; Frank J Gonzalez
Journal:  Drug Metab Dispos       Date:  2008-09-17       Impact factor: 3.922

2.  Individual and combined roles of CYP3A, P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel.

Authors:  Robert A B van Waterschoot; Jurjen S Lagas; Els Wagenaar; Hilde Rosing; Jos H Beijnen; Alfred H Schinkel
Journal:  Int J Cancer       Date:  2010-12-15       Impact factor: 7.396

3.  Inhibition of CYP3A4 expression by ketoconazole is mediated by the disruption of pregnane X receptor, steroid receptor coactivator-1, and hepatocyte nuclear factor 4alpha interaction.

Authors:  Yun-Ping Lim; Sheng-Chun Kuo; Ming-Liang Lai; Jin-Ding Huang
Journal:  Pharmacogenet Genomics       Date:  2009-01       Impact factor: 2.089

4.  Epigenetic regulation of transcriptional activity of pregnane X receptor by protein arginine methyltransferase 1.

Authors:  Ying Xie; Sui Ke; Nengtai Ouyang; Jinhan He; Wen Xie; Mark T Bedford; Yanan Tian
Journal:  J Biol Chem       Date:  2009-01-13       Impact factor: 5.157

5.  Cyclic AMP-dependent protein kinase signaling modulates pregnane x receptor activity in a species-specific manner.

Authors:  Kristin Lichti-Kaiser; Chenshu Xu; Jeff L Staudinger
Journal:  J Biol Chem       Date:  2009-01-13       Impact factor: 5.157

6.  A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.

Authors:  Nico Scheer; Jillian Ross; Anja Rode; Branko Zevnik; Sandra Niehaves; Nicole Faust; C Roland Wolf
Journal:  J Clin Invest       Date:  2008-09       Impact factor: 14.808

7.  The traditional Chinese herbal remedy tian xian activates pregnane X receptor and induces CYP3A gene expression in hepatocytes.

Authors:  Kristin Lichti-Kaiser; Jeff L Staudinger
Journal:  Drug Metab Dispos       Date:  2008-05-12       Impact factor: 3.922

8.  The structural basis of pregnane X receptor binding promiscuity.

Authors:  Chi-Ho Ngan; Dmitri Beglov; Aleksandra N Rudnitskaya; Dima Kozakov; David J Waxman; Sandor Vajda
Journal:  Biochemistry       Date:  2009-12-08       Impact factor: 3.162

9.  The aldo-keto reductase Akr1b7 gene is a common transcriptional target of xenobiotic receptors pregnane X receptor and constitutive androstane receptor.

Authors:  Ming-Jie Liu; Yuki Takahashi; Taira Wada; Jinhan He; Jie Gao; Yanan Tian; Song Li; Wen Xie
Journal:  Mol Pharmacol       Date:  2009-06-19       Impact factor: 4.436

10.  Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity.

Authors:  Jie Cheng; Xiaochao Ma; Kristopher W Krausz; Jeffrey R Idle; Frank J Gonzalez
Journal:  Drug Metab Dispos       Date:  2009-05-21       Impact factor: 3.922
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  19 in total

Review 1.  Transgenic mice and metabolomics for study of hepatic xenobiotic metabolism and toxicity.

Authors:  Frank J Gonzalez; Zhong-Ze Fang; Xiaochao Ma
Journal:  Expert Opin Drug Metab Toxicol       Date:  2015-04-02       Impact factor: 4.481

Review 2.  P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity.

Authors:  Karl-Dimiter Bissig; Weiguo Han; Mercedes Barzi; Nataliia Kovalchuk; Liang Ding; Xiaoyu Fan; Francis P Pankowicz; Qing-Yu Zhang; Xinxin Ding
Journal:  Drug Metab Dispos       Date:  2018-08-09       Impact factor: 3.922

Review 3.  Drug discovery technologies to identify and characterize modulators of the pregnane X receptor and the constitutive androstane receptor.

Authors:  Sergio C Chai; Wenwei Lin; Yongtao Li; Taosheng Chen
Journal:  Drug Discov Today       Date:  2019-02-04       Impact factor: 7.851

4.  Nuclear Receptors in Drug Metabolism, Drug Response and Drug Interactions.

Authors:  Chandra Prakash; Baltazar Zuniga; Chung Seog Song; Shoulei Jiang; Jodie Cropper; Sulgi Park; Bandana Chatterjee
Journal:  Nucl Receptor Res       Date:  2015

Review 5.  Pregnane X receptor as a target for treatment of inflammatory bowel disorders.

Authors:  Jie Cheng; Yatrik M Shah; Frank J Gonzalez
Journal:  Trends Pharmacol Sci       Date:  2012-05-18       Impact factor: 14.819

6.  Cytochrome P450 regulation by α-tocopherol in Pxr-null and PXR-humanized mice.

Authors:  Caroline H Johnson; Jessica A Bonzo; Jie Cheng; Kristopher W Krausz; Dong Wook Kang; Hans Luecke; Jeffrey R Idle; Frank J Gonzalez
Journal:  Drug Metab Dispos       Date:  2012-11-16       Impact factor: 3.922

7.  Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer.

Authors:  Jie Cheng; Zhong-Ze Fang; Kenjiro Nagaoka; Minoru Okamoto; Aijuan Qu; Naoki Tanaka; Shioko Kimura; Frank J Gonzalez
Journal:  J Pharmacol Exp Ther       Date:  2014-10-02       Impact factor: 4.030

8.  Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D3 through CYP3A4 induction in vitro and in vivo: implications for drug-induced osteomalacia.

Authors:  Zhican Wang; Yvonne S Lin; Leslie J Dickmann; Emma-Jane Poulton; David L Eaton; Johanna W Lampe; Danny D Shen; Connie L Davis; Margaret C Shuhart; Kenneth E Thummel
Journal:  J Bone Miner Res       Date:  2013-05       Impact factor: 6.741

9.  Role of human pregnane X receptor in high fat diet-induced obesity in pre-menopausal female mice.

Authors:  Krisstonia Spruiell; Dominique Z Jones; John M Cullen; Emmanuel M Awumey; Frank J Gonzalez; Maxwell A Gyamfi
Journal:  Biochem Pharmacol       Date:  2014-04-12       Impact factor: 5.858

10.  CITCO Directly Binds to and Activates Human Pregnane X Receptor.

Authors:  Wenwei Lin; Monicah Bwayi; Jing Wu; Yongtao Li; Sergio C Chai; Andrew D Huber; Taosheng Chen
Journal:  Mol Pharmacol       Date:  2019-12-27       Impact factor: 4.436
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