INTRODUCTION: The aim of this study was to evaluate the correlation between carotid siphon (CS) calcification and lacunar infarction caused by small-vessel disease. METHODS: This retrospective study included 445 patients (M/F = 256:189) older than 40 years (mean age 60.0 ± 12.3 years, range 41-98 years) without large intracranial lesions who had undergone both brain CT and MRI within an interval of 6 months. The patients were classified into three groups according to the number of lacunar infarctions: group I-zero infarctions (n = 328), group II-one to three infarctions (n = 94), and group III-four or more infarctions (n = 23). The severity of CS calcification was evaluated on CT and scored on a five-point scale (0-none, 1-stippled, 2-thin continuous or thick discontinuous, 3-thick continuous, 4-double tracts), and the calcification scores on both sides were summed. An ANOVA test was used to compare calcification scores among the three groups, and a logistic regression test was used to evaluate the influence of CS calcification and known cerebrovascular risk factors on the occurrence of lacunar infarction. RESULTS: On the ANOVA test, total calcification scores were significantly different among the three groups (group I = 1.28 ± 1.99, group II = 3.31 ± 2.39, group III = 4.36 ± 2.08; P < 0.05). Higher rates of lacunar infarction were associated with higher CS calcification scores. On the logistic regression test, CS calcification, age, and hypertension were significant risk factors for lacunar infarction (P < 0.05). CONCLUSION: CS calcification was correlated with the occurrence of lacunar infarction. The degree of CS calcification may be used to predict the possibility of a future lacunar infarction.
INTRODUCTION: The aim of this study was to evaluate the correlation between carotid siphon (CS) calcification and lacunar infarction caused by small-vessel disease. METHODS: This retrospective study included 445 patients (M/F = 256:189) older than 40 years (mean age 60.0 ± 12.3 years, range 41-98 years) without large intracranial lesions who had undergone both brain CT and MRI within an interval of 6 months. The patients were classified into three groups according to the number of lacunar infarctions: group I-zero infarctions (n = 328), group II-one to three infarctions (n = 94), and group III-four or more infarctions (n = 23). The severity of CS calcification was evaluated on CT and scored on a five-point scale (0-none, 1-stippled, 2-thin continuous or thick discontinuous, 3-thick continuous, 4-double tracts), and the calcification scores on both sides were summed. An ANOVA test was used to compare calcification scores among the three groups, and a logistic regression test was used to evaluate the influence of CS calcification and known cerebrovascular risk factors on the occurrence of lacunar infarction. RESULTS: On the ANOVA test, total calcification scores were significantly different among the three groups (group I = 1.28 ± 1.99, group II = 3.31 ± 2.39, group III = 4.36 ± 2.08; P < 0.05). Higher rates of lacunar infarction were associated with higher CS calcification scores. On the logistic regression test, CS calcification, age, and hypertension were significant risk factors for lacunar infarction (P < 0.05). CONCLUSION:CS calcification was correlated with the occurrence of lacunar infarction. The degree of CS calcification may be used to predict the possibility of a future lacunar infarction.
Authors: Rozemarijn Vliegenthart; Monika Hollander; Monique M B Breteler; Deirdre A M van der Kuip; Albert Hofman; Matthijs Oudkerk; Jacqueline C M Witteman Journal: Stroke Date: 2002-02 Impact factor: 7.914
Authors: S Spolveri; M C Baruffi; C Cappelletti; F Semerano; S Rossi; G Pracucci; D Inzitari Journal: Cerebrovasc Dis Date: 1998 May-Jun Impact factor: 2.762
Authors: Henk A Marquering; Paul J Nederkoorn; Leslie Bleeker; René van den Berg; Charles B Majoie Journal: Neuroradiology Date: 2012-10-02 Impact factor: 2.804
Authors: Leslie Bleeker; Henk A Marquering; René van den Berg; Paul J Nederkoorn; Charles B Majoie Journal: Neuroradiology Date: 2011-12-30 Impact factor: 2.804
Authors: Nikola Gotovac; Ivana Išgum; Max A Viergever; Geert J Biessels; Josip Fajdić; Birgitta K Velthuis; Mathias Prokop Journal: Eur Radiol Date: 2013-01-18 Impact factor: 5.315