PURPOSE OF REVIEW: The Notch pathway is an evolutionary conserved cell-cell communication mechanism that plays a key role in kidney development. Here, we will discuss a number of recently published papers describing the role of Notch signaling in kidney development, homeostasis, injury and repair. RECENT FINDINGS: Recent gene expression studies identified regulation of the Notch pathway in patients with chronic kidney disease (CKD). Mechanistic experiments performed using transgenic and knock-out mouse models indicate that Notch plays an important functional role in the development of proteinuria and renal fibrosis. Inhibition of the Notch pathway ameliorated diabetic kidney disease, nephrotic syndrome and fibrosis in different rodent models. SUMMARY: An increasing amount of evidence suggests that Notch plays a role in CKD development. Understanding the role of Notch signaling in the kidney can aid in the development of new therapeutics for CKD.
PURPOSE OF REVIEW: The Notch pathway is an evolutionary conserved cell-cell communication mechanism that plays a key role in kidney development. Here, we will discuss a number of recently published papers describing the role of Notch signaling in kidney development, homeostasis, injury and repair. RECENT FINDINGS: Recent gene expression studies identified regulation of the Notch pathway in patients with chronic kidney disease (CKD). Mechanistic experiments performed using transgenic and knock-out mouse models indicate that Notch plays an important functional role in the development of proteinuria and renal fibrosis. Inhibition of the Notch pathway ameliorated diabetic kidney disease, nephrotic syndrome and fibrosis in different rodent models. SUMMARY: An increasing amount of evidence suggests that Notch plays a role in CKD development. Understanding the role of Notch signaling in the kidney can aid in the development of new therapeutics for CKD.
Authors: David W Walsh; Sarah A Roxburgh; Paul McGettigan; Celine C Berthier; Desmond G Higgins; Matthias Kretzler; Clemens D Cohen; Sergio Mezzano; Derek P Brazil; Finian Martin Journal: Biochim Biophys Acta Date: 2007-10-11
Authors: Aoife M Waters; Megan Y J Wu; Tuncer Onay; Jacob Scutaru; Ju Liu; Corrinne G Lobe; Susan E Quaggin; Tino D Piscione Journal: J Am Soc Nephrol Date: 2008-03-12 Impact factor: 10.121
Authors: T Kobayashi; Y Terada; H Kuwana; H Tanaka; T Okado; M Kuwahara; S Tohda; S Sakano; S Sasaki Journal: Kidney Int Date: 2008-04-16 Impact factor: 10.612
Authors: Han Si; Ramandeep S Banga; Pinelopi Kapitsinou; Manjunath Ramaiah; Janis Lawrence; Ganesh Kambhampati; Antje Gruenwald; Erwin Bottinger; Daniel Glicklich; Vivian Tellis; Stuart Greenstein; David B Thomas; James Pullman; Melissa Fazzari; Katalin Susztak Journal: PLoS One Date: 2009-03-11 Impact factor: 3.240
Authors: Timothy D Cummins; Michael D Mendenhall; Michelle N Lowry; Erik A Korte; Michelle T Barati; Syed J Khundmiri; Sarah A Salyer; Jon B Klein; David W Powell Journal: Biochim Biophys Acta Date: 2011-10-05
Authors: Sebastian Martini; Viji Nair; Benjamin J Keller; Felix Eichinger; Jennifer J Hawkins; Ann Randolph; Carsten A Böger; Crystal A Gadegbeku; Caroline S Fox; Clemens D Cohen; Matthias Kretzler Journal: J Am Soc Nephrol Date: 2014-06-12 Impact factor: 10.121
Authors: Markus Gödel; Björn Hartleben; Nadja Herbach; Shuya Liu; Stefan Zschiedrich; Shun Lu; Andrea Debreczeni-Mór; Maja T Lindenmeyer; Maria-Pia Rastaldi; Götz Hartleben; Thorsten Wiech; Alessia Fornoni; Robert G Nelson; Matthias Kretzler; Rüdiger Wanke; Hermann Pavenstädt; Dontscho Kerjaschki; Clemens D Cohen; Michael N Hall; Markus A Rüegg; Ken Inoki; Gerd Walz; Tobias B Huber Journal: J Clin Invest Date: 2011-05-23 Impact factor: 14.808