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Literature DB >> 21952830

Notch in the kidney: development and disease.

Abstract

Notch signalling is a highly conserved cell-cell communication mechanism that regulates development, tissue homeostasis, and repair. Within the kidney, Notch has an important function in orchestrating kidney development. Recent studies indicate that Notch plays a key role in establishing proximal epithelial fate during nephron segmentation as well as the differentiation of principal cells in the renal collecting system. Notch signalling is markedly reduced in the adult kidney; however, increased Notch signalling has been noted in both acute and chronic kidney injury. Increased glomerular epithelial Notch signalling has been associated with albuminuria and glomerulosclerosis, while tubular epithelial Notch activation caused fibrosis development most likely inducing an improper epithelial repair pathway. Recent studies thereby indicate that Notch is a key regulator of kidney development, repair, and injury.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Receptors, Notch

Year: 2011 PMID： 21952830 PMCID： PMC3677191 DOI： 10.1002/path.2967

Source DB: PubMed Journal: J Pathol ISSN： 0022-3417 Impact factor: 7.996

100 in total

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Authors: Andrew P Weng; Adolfo A Ferrando; Woojoong Lee; John P Morris; Lewis B Silverman; Cheryll Sanchez-Irizarry; Stephen C Blacklow; A Thomas Look; Jon C Aster
Journal: Science Date: 2004-10-08 Impact factor: 47.728

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Journal: Nature Date: 1996-06-27 Impact factor: 49.962

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Journal: Am J Physiol Date: 1986-06

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Authors: J S Nye; R Kopan
Journal: Curr Biol Date: 1995-09-01 Impact factor: 10.834

5. Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4.

Authors: K Stark; S Vainio; G Vassileva; A P McMahon
Journal: Nature Date: 1994-12-15 Impact factor: 49.962

6. Hepatic ductular hypoplasia associated with characteristic facies, vertebral malformations, retarded physical, mental, and sexual development, and cardiac murmur.

Authors: D Alagille; M Odièvre; M Gautier; J P Dommergues
Journal: J Pediatr Date: 1975-01 Impact factor: 4.406

7. Syndromic paucity of interlobular bile ducts (Alagille syndrome or arteriohepatic dysplasia): review of 80 cases.

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Journal: J Pediatr Date: 1987-02 Impact factor: 4.406

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Journal: Pediatr Nephrol Date: 1987-07 Impact factor: 3.714

9. Signalling downstream of activated mammalian Notch.

Authors: S Jarriault; C Brou; F Logeat; E H Schroeter; R Kopan; A Israel
Journal: Nature Date: 1995-09-28 Impact factor: 49.962

10. An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells.

Authors: J S Nye; R Kopan; R Axel
Journal: Development Date: 1994-09 Impact factor: 6.868

53 in total

Review 1. Key metalloproteinase-mediated pathways in the kidney.

Authors: Tammo Ostendorf; Andreas Ludwig; Justyna Wozniak; Jürgen Floege
Journal: Nat Rev Nephrol Date: 2021-04-20 Impact factor: 28.314

Review 2. TGF-β: the master regulator of fibrosis.

Authors: Xiao-Ming Meng; David J Nikolic-Paterson; Hui Yao Lan
Journal: Nat Rev Nephrol Date: 2016-04-25 Impact factor: 28.314

Review 3. Renal interstitial fibrosis: mechanisms and evaluation.

Authors: Alton B Farris; Robert B Colvin
Journal: Curr Opin Nephrol Hypertens Date: 2012-05 Impact factor: 2.894

Review 4. Morphogen pathways in systemic sclerosis.

Authors: Christian Beyer; Jörg H W Distler
Journal: Curr Rheumatol Rep Date: 2013-01 Impact factor: 4.592

5. Notch ties a knot on fistula maturation.

Authors: Laura M Dember; Katalin Susztak
Journal: J Am Soc Nephrol Date: 2014-01-30 Impact factor: 10.121

6. Basal body proteins regulate Notch signaling through endosomal trafficking.

Authors: Carmen C Leitch; Sukanya Lodh; Victoria Prieto-Echagüe; Jose L Badano; Norann A Zaghloul
Journal: J Cell Sci Date: 2014-03-28 Impact factor: 5.285

7. PGC-1α Protects from Notch-Induced Kidney Fibrosis Development.

Authors: Seung Hyeok Han; Mei-Yan Wu; Bo Young Nam; Jung Tak Park; Tae-Hyun Yoo; Shin-Wook Kang; Jihwan Park; Frank Chinga; Szu-Yuan Li; Katalin Susztak
Journal: J Am Soc Nephrol Date: 2017-07-27 Impact factor: 10.121

Review 8. Notch in fibrosis and as a target of anti-fibrotic therapy.

Authors: Biao Hu; Sem H Phan
Journal: Pharmacol Res Date: 2016-04-21 Impact factor: 7.658

9. Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia-reperfusion injury.

Authors: Jason A Funk; Rick G Schnellmann
Journal: Toxicol Appl Pharmacol Date: 2013-10-03 Impact factor: 4.219

10. Aberrant Notch1-dependent effects on glomerular parietal epithelial cells promotes collapsing focal segmental glomerulosclerosis with progressive podocyte loss.

Authors: Toshiharu Ueno; Namiko Kobayashi; Makiko Nakayama; Yasutoshi Takashima; Takamoto Ohse; Ira Pastan; Jeffrey W Pippin; Stuart J Shankland; Noriko Uesugi; Taiji Matsusaka; Michio Nagata
Journal: Kidney Int Date: 2013-02-27 Impact factor: 10.612