Literature DB >> 21087860

Design and efficient synthesis of A-278637 derivatives as potential potassium channel opener.

Tuanjie Li1, Xiaodong Feng, Changsheng Yao, Chenxia Yu, Bei Jiang, Shujiang Tu.   

Abstract

A series of thieno[3,2-b]quinoline derivatives designed based on A-278637 scaffold, were synthesized efficiently via one-pot three-component reaction under solvent-free and catalyst-free conditions. This work provides a new compound library with potential biological activity for biomedical screening.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID: 21087860     DOI: 10.1016/j.bmcl.2010.10.127

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  3,3,6,6-Tetra-methyl-9-(1-methyl-1H-indol-2-yl)-1,2,3,4,5,6,7,8,9,10-deca-hydro-acridine-1,8-dione.

Authors:  Sema Oztürk Yildirim; Ray J Butcher; Ahmed El-Khouly; Cihat Safak; Rahime Simsek
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-11-17

2.  2,2,7,7-Tetra-methyl-1,2,3,4,5,6,7,8-octa-hydro-acridine-1,8-dione.

Authors:  Sema Oztürk Yildirim; Ray J Butcher; Rahime Simsek; Ahmed El-Khouly; Cihat Safak
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-12-15
  2 in total

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