Literature DB >> 2108603

Chromosomal mapping of a human phenol UDP-glucuronosyltransferase, GNT1.

D Harding1, S J Jeremiah, S Povey, B Burchell.   

Abstract

A 5' fragment of a full-length cDNA clone encoding a human phenol UDP-glucuronosyltransferase was used to produce a specific probe for this gene. DNA isolated from a panel of 18 human-rodent somatic cell hybrids was analysed by Southern-blot hybridization. The results indicate that this UDP-glucuronosyltransferase is encoded by a single gene, designated GNT1, located on human chromosome 2.

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Year:  1990        PMID： 2108603     DOI： 10.1111/j.1469-1809.1990.tb00356.x

Source DB:  PubMed          Journal:  Ann Hum Genet        ISSN： 0003-4800            Impact factor:   1.670


  12 in total

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Review 2.  Comparative map for mice and humans.

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3.  Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family.

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Journal:  J Clin Invest       Date:  1992-07       Impact factor: 14.808

5.  Cosegregation of intragenic markers with a novel mutation that causes Crigler-Najjar syndrome type I: implication in carrier detection and prenatal diagnosis.

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7.  Prediction of deleterious non-synonymous single-nucleotide polymorphisms of human uridine diphosphate glucuronosyltransferase genes.

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9.  Identification of two single base substitutions in the UGT1 gene locus which abolish bilirubin uridine diphosphate glucuronosyltransferase activity in vitro.

Authors:  L T Erps; J K Ritter; J H Hersh; D Blossom; N C Martin; I S Owens
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10.  Searching for tissue-specific expression pattern-linked nucleotides of UGT1A isoforms.

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