BACKGROUND: Animal models have shown that adipose-derived palmitoleic acid may serve as a lipokine that contributes to resistance to diet-induced obesity. Studies in humans have evaluated only plasma palmitoleic acid concentrations, which reflect stearoyl-coenzyme A desaturase 1 (SCD1) activity in the liver and are associated with increased risk of obesity. These apparent opposite effects of palmitoleic acid deserve further research in humans. Because carbohydrate intake can increase hepatic SCD1 activity, it could be used as a stratifying variable to disentangle the effects of adipose tissue SCD1 compared with the effects of liver SCD1 activity on obesity. OBJECTIVE: We examined whether the effects of adipose tissue palmitoleic acid and SCD1 activity were associated with decreased obesity prevalence and whether this association was modified by carbohydrate intake. DESIGN: Prevalence ratios (PRs) of obesity [body mass index (in kg/m²) > 30] were examined in a cross-sectional study in 1926 adults in Costa Rica. Two desaturation indexes (16:1/16:0 and 18:1/18:0) were used as surrogate measures of adipose tissue SCD1 activity. RESULTS: We observed a positive association between adipose tissue palmitoleic acid concentrations and obesity (PR for lowest compared with highest quintiles of palmitoleic acid: 2.27; 95% CI: 1.52, 3.38; P for trend < 0.0001). A significant association was also observed between obesity and adipose desaturation indexes. The association between adipose tissue palmitoleic acid concentrations and obesity was attenuated in persons with low carbohydrate intake. CONCLUSIONS: There is no direct evidence that adipose tissue palmitoleic acid behaves as a lipokine to reduce obesity occurrence in humans. However, the attenuation of the association by low carbohydrate intake warrants further research on adipose-derived palmitoleic acid and obesity risk.
BACKGROUND: Animal models have shown that adipose-derived palmitoleic acid may serve as a lipokine that contributes to resistance to diet-induced obesity. Studies in humans have evaluated only plasma palmitoleic acid concentrations, which reflect stearoyl-coenzyme A desaturase 1 (SCD1) activity in the liver and are associated with increased risk of obesity. These apparent opposite effects of palmitoleic acid deserve further research in humans. Because carbohydrate intake can increase hepatic SCD1 activity, it could be used as a stratifying variable to disentangle the effects of adipose tissue SCD1 compared with the effects of liver SCD1 activity on obesity. OBJECTIVE: We examined whether the effects of adipose tissue palmitoleic acid and SCD1 activity were associated with decreased obesity prevalence and whether this association was modified by carbohydrate intake. DESIGN: Prevalence ratios (PRs) of obesity [body mass index (in kg/m²) > 30] were examined in a cross-sectional study in 1926 adults in Costa Rica. Two desaturation indexes (16:1/16:0 and 18:1/18:0) were used as surrogate measures of adipose tissue SCD1 activity. RESULTS: We observed a positive association between adipose tissue palmitoleic acid concentrations and obesity (PR for lowest compared with highest quintiles of palmitoleic acid: 2.27; 95% CI: 1.52, 3.38; P for trend < 0.0001). A significant association was also observed between obesity and adipose desaturation indexes. The association between adipose tissue palmitoleic acid concentrations and obesity was attenuated in persons with low carbohydrate intake. CONCLUSIONS: There is no direct evidence that adipose tissue palmitoleic acid behaves as a lipokine to reduce obesity occurrence in humans. However, the attenuation of the association by low carbohydrate intake warrants further research on adipose-derived palmitoleic acid and obesity risk.
Authors: Alan D Attie; Ronald M Krauss; Mark P Gray-Keller; Alison Brownlie; Makoto Miyazaki; John J Kastelein; Aldons J Lusis; Anton F H Stalenhoef; Jonathan P Stoehr; Michael R Hayden; James M Ntambi Journal: J Lipid Res Date: 2002-11 Impact factor: 5.922
Authors: E I Park; E A Paisley; H J Mangian; D A Swartz; M X Wu; P J O'Morchoe; S R Behr; W J Visek; J Kaput Journal: J Nutr Date: 1997-04 Impact factor: 4.798
Authors: A Perez-Cornago; L Brennan; I Ibero-Baraibar; H H M Hermsdorff; A O'Gorman; M A Zulet; J Alfredo Martínez Journal: J Physiol Biochem Date: 2014-01-09 Impact factor: 4.158
Authors: M Kunešová; P Hlavatý; E Tvrzická; B Staňková; P Kalousková; N Viguerie; T M Larsen; M A van Baak; S A Jebb; J A Martinez; A F H Pfeiffer; A Kafatos; T Handjieva-Darlenska; M Hill; D Langin; A Zák; A Astrup; W H M Saris Journal: Physiol Res Date: 2012-10-25 Impact factor: 1.881
Authors: Leah Eissing; Thomas Scherer; Klaus Tödter; Uwe Knippschild; Jan Willem Greve; Wim A Buurman; Hans O Pinnschmidt; Sander S Rensen; Anna M Wolf; Alexander Bartelt; Joerg Heeren; Christoph Buettner; Ludger Scheja Journal: Nat Commun Date: 2013 Impact factor: 14.919
Authors: Alma M Astudillo; Clara Meana; Carlos Guijas; Laura Pereira; Patricia Lebrero; María A Balboa; Jesús Balsinde Journal: J Lipid Res Date: 2017-11-21 Impact factor: 5.922