Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Insights into Stearoyl-CoA Desaturase-1 Regulation of Systemic Metabolism.

Literature DB >> 29089222

Insights into Stearoyl-CoA Desaturase-1 Regulation of Systemic Metabolism.

Ahmed M ALJohani¹, Deeba N Syed², James M Ntambi³.

Abstract

Stearoyl-coenzyme A desaturase 1 (SCD1) is a central regulator of fuel metabolism and may represent a therapeutic target to control obesity and the progression of related metabolic diseases including type 2 diabetes and hepatic steatosis. SCD1 catalyzes the synthesis of monounsaturated fatty acids (MUFAs), mainly oleate and palmitoleate, which are important in controlling weight gain in response to feeding high carbohydrate diets. In this review, we evaluate the role of SCD1 isoform in the regulation of lipid and glucose metabolism in metabolic tissues. These highlights of recent findings are aimed toward advancing our understanding of the role of SCD1 in the development of metabolic diseases, which may help evaluate the possible health outcomes of modulating MUFA levels through targeting SCD1 activity.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2017 PMID： 29089222 PMCID： PMC5701860 DOI： 10.1016/j.tem.2017.10.003

Source DB: PubMed Journal: Trends Endocrinol Metab ISSN： 1043-2760 Impact factor: 12.015

67 in total

Review 1. Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk.

Authors: Jennifer H Stern; Joseph M Rutkowski; Philipp E Scherer
Journal: Cell Metab Date: 2016-05-10 Impact factor: 27.287

2. Triglyceride accumulation protects against fatty acid-induced lipotoxicity.

Authors: Laura L Listenberger; Xianlin Han; Sarah E Lewis; Sylvaine Cases; Robert V Farese; Daniel S Ory; Jean E Schaffer
Journal: Proc Natl Acad Sci U S A Date: 2003-03-10 Impact factor: 11.205

3. Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat.

Authors: Harini Sampath; Makoto Miyazaki; Agnieszka Dobrzyn; James M Ntambi
Journal: J Biol Chem Date: 2006-11-23 Impact factor: 5.157

4. Oleic and linoleic fatty acids downregulate Slc2a4/GLUT4 expression via NFKB and SREBP1 in skeletal muscle cells.

Authors: Ana Cláudia Poletto; Daniela Tomie Furuya; Aline David-Silva; Patrícia Ebersbach-Silva; Camilo Lellis Santos; Maria Lúcia Corrêa-Giannella; Marisa Passarelli; Ubiratan Fabres Machado
Journal: Mol Cell Endocrinol Date: 2014-12-05 Impact factor: 4.102

5. Hepatic oleate regulates liver stress response partially through PGC-1α during high-carbohydrate feeding.

Authors: Xueqing Liu; Maggie S Burhans; Matthew T Flowers; James M Ntambi
Journal: J Hepatol Date: 2016-03-11 Impact factor: 25.083

6. Fatty acid desaturases in human adipose tissue: relationships between gene expression, desaturation indexes and insulin resistance.

Authors: P Sjögren; J Sierra-Johnson; K Gertow; M Rosell; B Vessby; U de Faire; A Hamsten; M-L Hellenius; R M Fisher
Journal: Diabetologia Date: 2007-11-20 Impact factor: 10.122

7. SCD1 inhibition during 3T3-L1 adipocyte differentiation remodels triacylglycerol, diacylglycerol and phospholipid fatty acid composition.

Authors: Jessica C Ralston; David M Mutch
Journal: Prostaglandins Leukot Essent Fatty Acids Date: 2015-04-28 Impact factor: 4.006

8. The evolutionary history of the stearoyl-CoA desaturase gene family in vertebrates.

Authors: L Filipe C Castro; Jonathan M Wilson; Odete Gonçalves; Susana Galante-Oliveira; Eduardo Rocha; Isabel Cunha
Journal: BMC Evol Biol Date: 2011-05-19 Impact factor: 3.260

9. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase.

Authors: T Yamauchi; J Kamon; Y Minokoshi; Y Ito; H Waki; S Uchida; S Yamashita; M Noda; S Kita; K Ueki; K Eto; Y Akanuma; P Froguel; F Foufelle; P Ferre; D Carling; S Kimura; R Nagai; B B Kahn; T Kadowaki
Journal: Nat Med Date: 2002-10-07 Impact factor: 53.440

10. Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance.

Authors: Chong Yew Tan; Samuel Virtue; Steven Murfitt; Lee D Roberts; Lee D Robert; Yi Hui Phua; Martin Dale; Julian L Griffin; Francisco Tinahones; Philipp E Scherer; Antonio Vidal-Puig
Journal: Sci Rep Date: 2015-12-17 Impact factor: 4.379

46 in total

1. A conserved evolutionary mechanism permits Δ9 desaturation of very-long-chain fatty acyl lipids.

Authors: Yuanheng Cai; Xiao-Hong Yu; Jin Chai; Chang-Jun Liu; John Shanklin
Journal: J Biol Chem Date: 2020-06-11 Impact factor: 5.157

2. Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis : Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis.

Authors: Shenglong Zhu; Jingwei Zhang; Wei Wang; Xuan Jiang; Yong Q Chen
Journal: J Physiol Biochem Date: 2022-02-05 Impact factor: 4.158

3. Short-Term High-Fat Diet Fuels Colitis Progression in Mice Associated With Changes in Blood Metabolome and Intestinal Gene Expression.

Authors: Zhen-Hua Wu; Jing Yang; Lei Chen; Chuang Du; Qi Zhang; Shan-Shan Zhao; Xiao-Yu Wang; Jing Yang; Yang Liu; Demin Cai; Jian Du; Hui-Xin Liu
Journal: Front Nutr Date: 2022-06-07

Review 4. A Review of Metabolic Targets of Anticancer Nutrients and Nutraceuticals in Pre-Clinical Models of Triple-Negative Breast Cancer.

Authors: Alleigh Wiggs; Sabrina Molina; Susan J Sumner; Blake R Rushing
Journal: Nutrients Date: 2022-05-10 Impact factor: 6.706

5. Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II.

Authors: Keli Liu; Liangyu Lin; Qing Li; Yueqing Xue; Fanjun Zheng; Guan Wang; Chunxing Zheng; Liming Du; Mingyuan Hu; Yin Huang; Changshun Shao; Xiangyin Kong; Gerry Melino; Yufang Shi; Ying Wang
Journal: Proc Natl Acad Sci U S A Date: 2020-01-17 Impact factor: 11.205

6. Maternal high-fat diet during suckling programs visceral adiposity and epigenetic regulation of adipose tissue stearoyl-CoA desaturase-1 in offspring.

Authors: Laura Butruille; Lucie Marousez; Charlène Pourpe; Frédérik Oger; Simon Lecoutre; Daniel Catheline; Solvig Görs; Cornelia C Metges; Céline Guinez; Christine Laborie; Philippe Deruelle; Jérôme Eeckhoute; Christophe Breton; Philippe Legrand; Jean Lesage; Delphine Eberlé
Journal: Int J Obes (Lond) Date: 2019-01-08 Impact factor: 5.095

7. Gene Expression Profiles from Heart, Lung and Liver Samples of Total-Body-Irradiated Minipigs: Implications for Predicting Radiation-Induced Tissue Toxicity.

Authors: Sunita Chopra; Maria Moroni; Shannon Martello; Michelle Bylicky; Jared May; Bernadette Hritzo; Laurel MacMillan; C Norman Coleman; Molykutty J Aryankalayil
Journal: Radiat Res Date: 2020-10-02 Impact factor: 2.841