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Literature DB >> 21082080

Identification of dihydropyridines that reduce cellular tau levels.

Christopher G Evans¹, Umesh K Jinwal, Leah N Makley, Chad A Dickey, Jason E Gestwicki.

Abstract

A series of dihydropyridines were identified that have an effect on the accumulation of tau, an important target in Alzheimer's disease. The dihydropyridine collection was expanded using the Hantzsch multicomponent reaction to develop preliminary structure-activity relationships.

Entities: CellLine Chemical Disease Gene Species

Mesh：

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Year: 2010 PMID： 21082080 PMCID： PMC3251959 DOI： 10.1039/c0cc02253e

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

14 in total

1. The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments.

Authors: Sadasivam Jeganathan; Martin von Bergen; Eva-Maria Mandelkow; Eckhard Mandelkow
Journal: Biochemistry Date: 2008-09-11 Impact factor: 3.162

2. Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines.

Authors: C M Wischik; P C Edwards; R Y Lai; M Roth; C R Harrington
Journal: Proc Natl Acad Sci U S A Date: 1996-10-01 Impact factor: 11.205

Review 3. Neuropathological stageing of Alzheimer-related changes.

Authors: H Braak; E Braak
Journal: Acta Neuropathol Date: 1991 Impact factor: 17.088

4. Synthesis of new acridines and hydrazones derived from cyclic beta-diketone for cytotoxic and antiviral evaluation.

Authors: Osama I el-Sabbagh; Hanaa M Rady
Journal: Eur J Med Chem Date: 2009-04-08 Impact factor: 6.514

Review 5. Tau mutations in neurodegenerative diseases.

Authors: Michael S Wolfe
Journal: J Biol Chem Date: 2008-10-22 Impact factor: 5.157

6. Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology.

Authors: Salvatore Oddo; Antonella Caccamo; Bert Tseng; David Cheng; Vitaly Vasilevko; David H Cribbs; Frank M LaFerla
Journal: J Neurosci Date: 2008-11-19 Impact factor: 6.167

Review 7. Tau pathophysiology in neurodegeneration: a tangled issue.

Authors: Tara L Spires-Jones; William H Stoothoff; Alix de Calignon; Phillip B Jones; Bradley T Hyman
Journal: Trends Neurosci Date: 2009-01-21 Impact factor: 13.837

8. Enantioselective organocatalytic Hantzsch synthesis of polyhydroquinolines.

Authors: Christopher G Evans; Jason E Gestwicki
Journal: Org Lett Date: 2009-07-16 Impact factor: 6.005

Review 9. Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases.

Authors: Michael P Mazanetz; Peter M Fischer
Journal: Nat Rev Drug Discov Date: 2007-06 Impact factor: 84.694

Review 10. Chaperone signalling complexes in Alzheimer's disease.

Authors: John Koren; Umesh K Jinwal; Daniel C Lee; Jeffrey R Jones; Cody L Shults; Amelia G Johnson; Laura J Anderson; Chad A Dickey
Journal: J Cell Mol Med Date: 2009-04 Impact factor: 5.310

11 in total

Review 1. Alzheimer mechanisms and therapeutic strategies.

Authors: Yadong Huang; Lennart Mucke
Journal: Cell Date: 2012-03-16 Impact factor: 41.582

2. Transcriptional Inhibitors Identified in a 160,000-Compound Small-Molecule DUX4 Viability Screen.

Authors: Si Ho Choi; Darko Bosnakovski; Jessica M Strasser; Erik A Toso; Michael A Walters; Michael Kyba
Journal: J Biomol Screen Date: 2016-05-31

Review 3. Tau Protein Squired by Molecular Chaperones During Alzheimer's Disease.

Authors: Nalini Vijay Gorantla; Subashchandrabose Chinnathambi
Journal: J Mol Neurosci Date: 2018-09-28 Impact factor: 3.444

4. DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau.

Authors: Jose F Abisambra; Umesh K Jinwal; Amirthaa Suntharalingam; Karthik Arulselvam; Sarah Brady; Matthew Cockman; Ying Jin; Bo Zhang; Chad A Dickey
Journal: J Mol Biol Date: 2012-02-15 Impact factor: 5.469

5. Intercepted-Knoevenagel condensation for the synthesis of unsymmetrical fused-tricyclic 4H-pyrans.

Authors: Charles Shearer; Oriane Desaunay; Stephen Zorc; Alexis D Richaud; Shyam S Samanta; Nagalakshmi Jeedimalla; Stéphane P Roche
Journal: Tetrahedron Date: 2019-09-17 Impact factor: 2.457

6. Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation.

Authors: Sidhartha M Chafekar; Susanne Wisén; Andrea D Thompson; AnaLisa Echeverria; Gladis M Walter; Christopher G Evans; Leah N Makley; Jason E Gestwicki; Martin L Duennwald
Journal: ACS Chem Biol Date: 2012-06-22 Impact factor: 5.100

7. Lanthanide and asymmetric catalyzed syntheses of sterically hindered 4-isoxazolyl-1,4-dihydropyridines and 4-isoxazolyl-quinolones.

Authors: Scott A Steiger; Chun Li; Charles F Campana; Nicholas R Natale
Journal: Tetrahedron Lett Date: 2016-01-20 Impact factor: 2.415

Review 8. The molecular diversity scope of 1,3-indandione in organic synthesis.

Authors: Shima Asadi; Ghodsi Mohammadi Ziarani
Journal: Mol Divers Date: 2015-05-10 Impact factor: 2.943

9. Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice.

Authors: Mala V Rao; Mary Kate McBrayer; Jabbar Campbell; Asok Kumar; Audrey Hashim; Henry Sershen; Philip H Stavrides; Masuo Ohno; Michael Hutton; Ralph A Nixon
Journal: J Neurosci Date: 2014-07-09 Impact factor: 6.167

10. 3-Acetyl-2-methyl-4-(pyridin-3-yl)-1,4-di-hydro-indeno-[1,2-b]pyridin-5-one.

Authors: Imants Bisenieks; Anatoly Mishnev; Imanta Bruvere; Brigita Vigante; Zigmars Andzans
Journal: Acta Crystallogr Sect E Struct Rep Online Date: 2013-04-13